{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:31:42Z","timestamp":1783049502355,"version":"3.54.6"},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1111\/cge.14018","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T03:09:47Z","timestamp":1625108987000},"page":"484-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>KRAS<\/scp>\n                    mutation identified in a patient with melorheostosis and extended lymphangiomatosis treated with sirolimus and trametinib"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8045-1079","authenticated-orcid":false,"given":"Clara","family":"Lacasta\u2010Plasin","sequence":"first","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4680-881X","authenticated-orcid":false,"given":"Victor","family":"Martinez\u2010Glez","sequence":"additional","affiliation":[{"name":"Vascular Malformations Section Institute of Medical and Molecular Genetics, INGEMM\u2010IdiPAZ, Hospital Universitario La Paz  Madrid Spain"},{"name":"CIBERER Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras, ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Rodriguez\u2010Laguna","sequence":"additional","affiliation":[{"name":"Vascular Malformations Section Institute of Medical and Molecular Genetics, INGEMM\u2010IdiPAZ, Hospital Universitario La Paz  Madrid Spain"},{"name":"CIBERER Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras, ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cervantes\u2010Pardo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca Pediatrics. Murcia  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Martinez\u2010Menchon","sequence":"additional","affiliation":[{"name":"Universidad Complutense de Madrid Facultad de Medicina Madrid  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Sanchez\u2010Jimenez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca Pediatrics. Murcia  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minia","family":"Campos\u2010Dominguez","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"},{"name":"Universidad Complutense de Madrid Facultad de Medicina Madrid  Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1453"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03720-z"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.04.010"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1118-1"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0479-2"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.14018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cge.14018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.14018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T19:36:47Z","timestamp":1693337807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cge.14018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/cge.14018"],"URL":"https:\/\/doi.org\/10.1111\/cge.14018","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/CGE.14018\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.14018\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.14018\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.14018\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.14018\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.14018\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.14018\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.14018\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.14018\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]},"assertion":[{"value":"2021-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}