{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:34:50Z","timestamp":1785926090948,"version":"3.56.0"},"reference-count":195,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T00:00:00Z","timestamp":1625961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Parkinson's disease (PD) is the second most common and progressive neurodegenerative disease globally, with major symptoms like bradykinesia, impaired posture, and tremor. Several genetic and environmental factors have been identified but elucidating the main factors have been challenging due to the disease's complex nature. Diagnosis, prognosis, and management of such diseases are challenging and require effective targeted attention in developing countries. Recently, PD is growing rapidly in many crowded Asian countries as an alarming threat with inadequate knowledge of its prevalence, genetic architecture, and geographic distribution. This study gave an in\u2010depth overview of the prevalence, incidence and genomic\/genetics studies published so far in the Asian population. To the best of our knowledge, PD has increased significantly in several Asian countries, including China, South Korea, Japan, Thailand, and Israel over the past few years, requiring a greater level of care and attention. Genetic screening of families with PD at national levels and establishing an official database of PD cases are essential to get a comprehensive and conclusive view of the exact prevalence and genetic diversity of PD in the Asian population to properly manage and treat the disease.<\/jats:p>","DOI":"10.1111\/cge.14019","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T14:28:23Z","timestamp":1625149703000},"page":"659-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Recalling the pathology of Parkinson's disease; lacking exact figure of prevalence and genetic evidence in Asia with an alarming outcome: A time to step\u2010up"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0309-1230","authenticated-orcid":false,"given":"Arif","family":"Mahmood","sequence":"first","affiliation":[{"name":"Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences Central South University  Changsha Hunan China"},{"name":"Institute of Molecular Precision Medicine, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abid Ali","family":"Shah","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6729-9746","authenticated-orcid":false,"given":"Muhammad","family":"Umair","sequence":"additional","affiliation":[{"name":"Medical Genomics Research Department King Abdullah International Medical Research Center (KAIMRC), King Saud bin Abdul\u2010Aziz University for Health Sciences, Ministry of National Guard\u2013Health Affairs (MNGHA)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amjad","family":"Khan","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Biological Sciences University of Lakki Marwat  Lakki Marwat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-1628-9_10"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.13"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00568-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2017.00177"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1154-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.028738"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25150"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23687"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012143432404"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.0947"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp012"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2016.11.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2045"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.10.023"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.11.005"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70117-0"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.104695"},{"key":"e_1_2_10_21_1","first-page":"1","article-title":"Variations in incidence and prevalence of Parkinson's disease in Taiwan: a population\u2010based nationwide study","volume":"2016","author":"Liu CC","year":"2016","journal-title":"Parkinsons Dis"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.12.403"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109908"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26060"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.131045"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827deb74"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25664"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23462"},{"key":"e_1_2_10_29_1","first-page":"2012","article-title":"Nonmotor symptoms in Parkinsons disease in 2012: relevant clinical aspects","volume":"2012","author":"Bonnet AM","year":"2012","journal-title":"Parkinsons Dis"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02056.x"},{"key":"e_1_2_10_31_1","volume-title":"World Population Ageing 2019","author":"Department of Economic and Social Affairs UN","year":"2019"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.020982"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.9.1358"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000201565"},{"issue":"3","key":"e_1_2_10_35_1","first-page":"7","article-title":"Epidemiology of Parkinson's disease in a Japanese City","volume":"40","author":"Harada H","year":"1983","journal-title":"Int Classif"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.35.276"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000213219"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000065527"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-019-1332-7"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2005.04.007"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10619"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03683.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21153"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22041"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20081034"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200706010-00004"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1992.tb08051.x"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117721"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.5.1270"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120210"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg068"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-7664-6"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-013-1092-z"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/576564"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000247740.47667.03"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30295-3"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-2011-11024"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060070045013"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10445"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70801-1"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00434.x"},{"key":"e_1_2_10_62_1","first-page":"1","article-title":"Prevalence of Alzheimer's disease and Parkinson's disease in China: An updated systematical analysis","volume":"12","author":"Cui L","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.9.1679"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2015.05.014"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520360039008"},{"key":"e_1_2_10_66_1","doi-asserted-by":"crossref","unstructured":"RazdanS RoshanLK MottaA KaulS BhattRK.Prevalence and pattern of major neurological disorders in rural.1994;13(1981):113\u2010119.","DOI":"10.1159\/000110368"},{"issue":"2","key":"e_1_2_10_67_1","first-page":"47","article-title":"Neuroepidemiology of major neurological disorders in rural Bengal","volume":"44","author":"Das SK","year":"1996","journal-title":"Neurol India"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.149365"},{"issue":"2","key":"e_1_2_10_69_1","first-page":"163","article-title":"A random sample survey for prevalence of major neurological disorders in Kolkata","volume":"124","author":"Das SK","year":"2006","journal-title":"Indian J Med Res"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f735a7"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2016.07.003"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1159\/000515030"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2006.09.005"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2018.14.4.478"},{"key":"e_1_2_10_75_1","unstructured":"KondoK ShibasakiH. Epidemiology of Parkinson's disease. Clues for etiology. Paper presented at:12th World Congress of Neurology International Congress Series 548.Excerpta Medica Amsterdam.1981:233."},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S86329"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S77391"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110316"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1159\/000048614"},{"issue":"1","key":"e_1_2_10_80_1","first-page":"32","article-title":"The prevalence of Parkinson's disease in an Arab population, Wadi Ara, Israel","volume":"12","author":"Masalha R","year":"2010","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334440"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480510"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000128090.79756.10"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1988-x"},{"issue":"3","key":"e_1_2_10_85_1","first-page":"109","article-title":"A population\u2010based survey to determine the prevalence of movement disorders in Orhangazi District of Bursa, Turkey","volume":"15","author":"Ozbek SE","year":"2009","journal-title":"Turkish J Neurol"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.11.272"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.17340\/jkna.2017.4.1"},{"issue":"6","key":"e_1_2_10_88_1","first-page":"363","article-title":"The incidence and prevalence of Parkinson's disease in the People's Republic of China","volume":"12","author":"Wang Y","year":"1991","journal-title":"Zhonghua Liuxingbingxue Zazhi"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25426"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.07.003"},{"issue":"12","key":"e_1_2_10_91_1","first-page":"1075","article-title":"Clinical spectrum of Parkinson's disease from Pakistan","volume":"47","author":"Khealani BA","year":"2006","journal-title":"Singapore Med J"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-017-2873-5"},{"issue":"6","key":"e_1_2_10_93_1","first-page":"845","article-title":"Study of prevalence of Parkinson \u2019 s disease in elderly population in Rawalpindi","volume":"4","author":"Imtiaz N","year":"2016","journal-title":"Pakistan"},{"issue":"3","key":"e_1_2_10_94_1","first-page":"16","article-title":"Frequency of non motor symptoms among patients of parkinsoints disease in Pakistan","volume":"13","author":"Ahmad I","year":"2016","journal-title":"J Pakistan Psychiatr Soc"},{"issue":"1","key":"e_1_2_10_95_1","first-page":"8","article-title":"Frequency of non\u2010motor symptoms in parkinson disease: experience from Pakistan","volume":"12","author":"Saad S","year":"2017","journal-title":"Pakistan J Neurol Sci"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.5296\/jbls.v4i1.2625"},{"issue":"3","key":"e_1_2_10_97_1","first-page":"363","article-title":"Neurological disorder burden in Faisalabad, Punjab\u2010Pakistan: data from the major tertiary care centers of the city","volume":"12","author":"Hussain G","year":"2017","journal-title":"Pakistan J Neurol Sci"},{"issue":"4","key":"e_1_2_10_98_1","first-page":"5","article-title":"Burden and pattern of neurological diseases seen in neurology department of a tertiary care hospital in Baluchistan","volume":"12","author":"Akbar W","year":"2017","journal-title":"Pakistan J Neurol Sci."},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019172"},{"key":"e_1_2_10_100_1","first-page":"S97","article-title":"Prevalence, distribution and management of Parkinson among Pakistani population","volume":"33","author":"Naureen S","year":"2018","journal-title":"Mov Disorders"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323389"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.3329\/jninb.v5i2.43013"},{"issue":"2","key":"e_1_2_10_103_1","first-page":"36","article-title":"Frequency and risk factors Association of Fall among the idiopathic Parkinson's patients in Jashore, Bangladesh","volume":"7","author":"Kumar AG","year":"2019","journal-title":"Am J Intern Med"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.3329\/jninb.v4i2.38927"},{"issue":"2","key":"e_1_2_10_105_1","first-page":"63","article-title":"Quality of life in patients with Parkinson's disease: translation and psychometric evaluation of the Iranian version of PDQ\u201039","volume":"15","author":"Nojomi M","year":"2010","journal-title":"J Res Med Sci"},{"issue":"1","key":"e_1_2_10_106_1","first-page":"19","article-title":"Demographic study of parkinson's disease in Iran: data on 1656 cases","volume":"10","author":"Roohani M","year":"2011","journal-title":"Iran J Neurol."},{"issue":"3","key":"e_1_2_10_107_1","first-page":"118","article-title":"Evaluation of non\u2010motor symptoms and their impact on quality of life in patients with Parkinson's disease, Isfahan","volume":"16","author":"Mirmosayyeb O","year":"2017","journal-title":"Iran Iran J Neurol"},{"issue":"1","key":"e_1_2_10_108_1","first-page":"6","article-title":"Demographic features and clinical characteristics of patients with Parkinson's disease in Isfahan","volume":"17","author":"Salari M","year":"2018","journal-title":"Iran. Iran J Neurol"},{"issue":"4","key":"e_1_2_10_109_1","first-page":"151","article-title":"Cognitive impairments in Parkinson's disease: evidence from an Iranian population","volume":"11","author":"Ashrafi F","year":"2012","journal-title":"Iran J Neurol"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/1108\/1\/012064"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004353"},{"issue":"2","key":"e_1_2_10_112_1","first-page":"S727","article-title":"The prevalence of gastrointestinal symptoms in Parkinson's disease patients in Bethesda hospital, Yogyakarta, Indonesia","volume":"33","author":"Jody A","year":"2018","journal-title":"Mov Disord"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26527"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090278"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.06.007"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/33416"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/26652"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00555-2"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077209"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20256"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.11.1777"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16983-3"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi215"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1884"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000338144.10967.2b"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.01.015"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp044"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21415"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.08.009"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2007.11.013"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24553"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22373"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt570"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3589"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.01.014"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30179-0"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa279"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000269323.21969.db"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2017.12.007"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-017-0780-8"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)97611-8"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(97)80033-9"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-010-0102-x"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2003.11.004"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.11.016"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.485"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24045"},{"key":"e_1_2_10_148_1","doi-asserted-by":"crossref","unstructured":"DuvoisinRC.Is Parkinson's disease acquired or inherited?2017;11(1):151\u2010155.","DOI":"10.1017\/S031716710004631X"},{"issue":"1","key":"e_1_2_10_149_1","first-page":"S66\u2010S70","article-title":"Role of mendelian genes in \u201csporadic\u201d Parkinson's disease","volume":"18","author":"Lesage S","year":"2012","journal-title":"Park Relat Disord"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz205"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1809969115"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26996"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01398-9"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0542-2"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.03.014"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.06.011"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32576"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.12.020"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197271"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0353-7"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0354-6"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.10.007"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0355-5"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.10.004"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906079106"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26875"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.12.015"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.12.021"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26900"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.03.007"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1071"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.487"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.07.011"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.01.019"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27864"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30320-5"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201700067"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-015-0041-3"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.04.05"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.06.025"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1248127"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2010.12.005"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3118"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1212-4"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3390"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-00735-5"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119675109"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2579"},{"issue":"1","key":"e_1_2_10_189_1","article-title":"Estimation of the 2020 global population of Parkinson's disease (PD)","volume":"35","author":"Maserejian N","year":"2020","journal-title":"Mov Disord."},{"issue":"1","key":"e_1_2_10_190_1","first-page":"1","article-title":"Current and projected future economic burden of Parkinson's disease in the U.S","volume":"6","author":"Yang W","year":"2020","journal-title":"Npj Park Dis"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30026-0"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110361"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mgene.2019.100559"},{"key":"e_1_2_10_194_1","unstructured":"UmairM AhmadF UllahA.Whole exome sequencing as a diagnostic tool for genetic disorders in Pakistan.2018;57(2):90\u201091."},{"key":"e_1_2_10_195_1","unstructured":"OMIM \u2010 Online Mendelian Inheritance in Man.https:\/\/www.omim.org\/. Accessed April 20 2021."},{"key":"e_1_2_10_196_1","unstructured":"HGMD.http:\/\/www.hgmd.cf.ac.uk\/ac\/index.php. Accessed April 20 2021."}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.14019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cge.14019","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cge.14019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:30:31Z","timestamp":1693182631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cge.14019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,11]]},"references-count":195,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/cge.14019"],"URL":"https:\/\/doi.org\/10.1111\/cge.14019","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/CGE.14019\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.14019\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.14019\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.14019\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.14019\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/CGE.14019\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,11]]},"assertion":[{"value":"2021-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}