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These phenotypically heterogeneous entities have been grouped as\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    \u2010Related Overgrowth Spectrum disorders (PROS). Deep sequencing technologies have facilitated detection of low\u2010level mosaic, often necessitating testing of tissues other than blood. Since clinical management practices vary considerably among healthcare professionals and services across different countries, a consensus on management guidelines is needed. Clinical heterogeneity within this spectrum leads to challenges in establishing management recommendations, which must be based on patient\u2010specific considerations. Moreover, as most of these conditions are rare, affected families may lack access to the medical expertise that is needed to help address the multi\u2010system and often complex medical issues seen with PROS. In March 2019, macrocephaly\u2010capillary malformation (M\u2010CM) patient organizations hosted an expert meeting in Manchester, United Kingdom, to help address these challenges with regards to M\u2010CM syndrome. We have expanded the scope of this project to cover PROS and developed this consensus statement on the preferred approach for managing affected individuals based on our current knowledge.\n                  <\/jats:p>","DOI":"10.1111\/cge.14027","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T23:58:14Z","timestamp":1625788694000},"page":"32-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["A standard of care for individuals with\n                    <scp>\n                      <i>PIK3CA<\/i>\n                    <\/scp>\n                    \u2010related disorders: An international expert consensus statement"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8890-7544","authenticated-orcid":false,"given":"Sofia","family":"Douzgou","sequence":"first","affiliation":[{"name":"Department of Medical Genetics Haukeland University Hospital  Bergen Norway"},{"name":"Manchester Centre for Genomic Medicine, St Mary's Hospital Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre  Manchester UK"},{"name":"Division of Evolution and Genomic Sciences School of Biological Sciences, University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myfanwy","family":"Rawson","sequence":"additional","affiliation":[{"name":"Manchester Centre for Genomic Medicine, St Mary's Hospital Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-8439","authenticated-orcid":false,"given":"Eulalia","family":"Baselga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Sant Joan de D\u00e9u, Passeig de Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moise","family":"Danielpour","sequence":"additional","affiliation":[{"name":"Board of Governors Regenerative Medicine Institute Cedars\u2010Sinai Medical Centre  Los Angeles California USA"},{"name":"Department of Neurosurgery Cedars\u2010Sinai Medical Centre  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Faivre","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Anomalies du D\u00e9veloppement et Syndromes Malformatifs, FHU TRANSLAD H\u00f4pital d'Enfants  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8074-0567","authenticated-orcid":false,"given":"Alon","family":"Kashanian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Cedars\u2010Sinai Medical Centre  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8250-164X","authenticated-orcid":false,"given":"Kim M.","family":"Keppler\u2010Noreuil","sequence":"additional","affiliation":[{"name":"Division of Genetics and Metabolism, Department of Paediatrics University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-6303","authenticated-orcid":false,"given":"Paul","family":"Kuentz","sequence":"additional","affiliation":[{"name":"Oncobiologie G\u00e9n\u00e9tique Bioinformatique PCBio, CHU  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1211-9979","authenticated-orcid":false,"given":"Grazia M. S.","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Erasmus MC University Medical Centre  Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Cecile","family":"Maniere","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence, Maladies orales et dentaires rares, P\u00f4le de M\u00e9decine et Chirurgie Bucco\u2010dentaires H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4680-881X","authenticated-orcid":false,"given":"Victor","family":"Martinez\u2010Glez","sequence":"additional","affiliation":[{"name":"IdiPAZ Research Institute  Madrid Spain"},{"name":"Centre for Biomedical Network Research on Rare Diseases (CIBERER), CIBER, Institute of Health Carlos III  Madrid Spain"},{"name":"Institute of Medical and Molecular Genetics (INGEMM) La Paz University Hospital  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