{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:40:35Z","timestamp":1791582035947,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["764002\u2010HE01"],"award-info":[{"award-number":["764002\u2010HE01"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010724","name":"Health Systems Research Institute","doi-asserted-by":"publisher","award":["63\u2010113"],"award-info":[{"award-number":["63\u2010113"]}],"id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","award":["P\u201019\u201051269"],"award-info":[{"award-number":["P\u201019\u201051269"]}],"id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["DPG6180001"],"award-info":[{"award-number":["DPG6180001"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["RSA6280001"],"award-info":[{"award-number":["RSA6280001"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To maximize the potential of genomics in medicine, it is essential to establish databases of genomic variants for ethno\u2010geographic groups that can be used for filtering and prioritizing candidate pathogenic variants. Populations with non\u2010European ancestry are poorly represented among current genomic variant databases. Here, we report the first high\u2010density survey of genomic variants for the Thai population, the Thai Reference Exome (T\u2010REx) variant database. T\u2010REx comprises exome sequencing data of 1092 unrelated Thai individuals. The targeted exome regions common among four capture platforms cover 30.04 Mbp on autosomes and chromosome X. 345\u2009681 short variants (18.27% of which are novel) and 34\u2009907 copy number variations were found. Principal component analysis on 38\u2009469 single nucleotide variants present worldwide showed that the Thai population is most genetically similar to East and Southeast Asian populations. Moreover, unsupervised clustering revealed six Thai subpopulations consistent with the evidence of gene flow from neighboring populations. The prevalence of common pathogenic variants in T\u2010REx was investigated in detail, which revealed subpopulation\u2010specific patterns, in particular variants associated with erythrocyte disorders such as the HbE variant in\n                    <jats:italic>HBB<\/jats:italic>\n                    and the Viangchan variant in\n                    <jats:italic>G6PD<\/jats:italic>\n                    . T\u2010REx serves as a pivotal addition to the current databases for genomic medicine.\n                  <\/jats:p>","DOI":"10.1111\/cge.14060","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T14:56:02Z","timestamp":1631112962000},"page":"703-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The Thai reference exome (T\u2010REx) variant database"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1856-0589","authenticated-orcid":false,"given":"Vorasuk","family":"Shotelersuk","sequence":"first","affiliation":[{"name":"Center of Excellence for Medical Genomics, Medical Genomics Cluster, Department of Pediatrics, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Excellence Center for Genomics and Precision Medicine King Chulalongkorn Memorial Hospital, the Thai Red Cross Society  Bangkok 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