{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:14:17Z","timestamp":1780611257942,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2021\u20101\u2010I2M\u2010011"],"award-info":[{"award-number":["2021\u20101\u2010I2M\u2010011"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2011BAI11B04"],"award-info":[{"award-number":["2011BAI11B04"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Elevated serum uric acid (UA) level has been shown to be influenced by multiple genetic variants, but it remains uncertain how UA\u2010associated variants differ in their influence on hyperuricemia risk in people taking antihypertensive drugs. We examined a total of 43 UA\u2010related variants at 29 genes in 1840 patients with hypertension from a community\u2010based longitudinal cohort during a median 2.25\u2010year follow\u2010up (including 1031 participants with normal UA, 440 prevalent hyperuricemia at baseline, and 369 new\u2010onset hyperuricemia). Compared with the wild\u2010type genotypes, patients carrying the\n                    <jats:italic>SLC2A9<\/jats:italic>\n                    rs3775948G allele or the rs13129697G allele had decreased risk of hyperuricemia, while patients carrying the\n                    <jats:italic>SLC2A9<\/jats:italic>\n                    rs11722228T allele had increased risk of hyperuricemia, after adjustment for cardiovascular risk factors and correction for multiple comparisons; moreover, these associations were modified by the use of diuretics, \u03b2\u2010blockers, or angiotensin converting enzyme inhibitors. The rs10821905A allele of\n                    <jats:italic>A1CF<\/jats:italic>\n                    gene was associated with increased risk of hyperuricemia, and this risk was enhanced by diuretics use. The studied variants were not observed to confer risk for incident cardiovascular events during the follow\u2010up. In conclusion, the genes\n                    <jats:italic>SLC2A9<\/jats:italic>\n                    and\n                    <jats:italic>A1CF<\/jats:italic>\n                    may serve as potential genetic markers for hyperuricemia risk in relation to antihypertensive drugs therapy in Chinese hypertensive patients.\n                  <\/jats:p>","DOI":"10.1111\/cge.14110","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T04:31:17Z","timestamp":1642048277000},"page":"411-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genetic risk of hyperuricemia in hypertensive patients associated with antihypertensive drug therapy: A longitudinal study"],"prefix":"10.1111","volume":"101","author":[{"given":"Yu","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases Peking Union Medical College &amp; Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases Peking Union Medical College &amp; Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases Peking Union Medical College &amp; Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases Peking Union 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