{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:47:11Z","timestamp":1792594031461,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Polydactyly or polydactylism, also known as a hyperdactyly, is a congenital limb defect with various morphologic phenotypes. Apart from physical and functional impairments, the presence of polydactyly is an indication of an underlying syndrome in the newborn. Usually, it follows as an autosomal dominant\/recessive inheritance pattern with defects in the limb development's anteroposterior patterning. Although mutations in several genes have been associated with polydactyly; however, the exact underlying cause, pathways, and disease mechanisms are still unexplored, thus making it of multi\u2010factorial origin. Polydactyly is divided into three subtypes; radial, ulnar, and central polydactyly. So far, 11 loci (PAPA1\u2010PAPA11) and seven human genes have been reported to cause non\u2010syndromic postaxial polydactyly in humans, including the\n                    <jats:italic>ZNF141<\/jats:italic>\n                    ,\n                    <jats:italic>GLI3<\/jats:italic>\n                    ,\n                    <jats:italic>IQCE<\/jats:italic>\n                    ,\n                    <jats:italic>GLI1<\/jats:italic>\n                    ,\n                    <jats:italic>FAM92A1<\/jats:italic>\n                    ,\n                    <jats:italic>KIAA0825<\/jats:italic>\n                    , and\n                    <jats:italic>DACH1<\/jats:italic>\n                    . In this review, we discuss emerging evidences of clinical and molecular characterization of polydactyly types in term of the involvement of newly associated genes and loci for non\u2010syndromic postaxial polydactyly, and how these might impact our understanding of the genetic mechanisms and molecular etiology involved in the cause of polydactyly.\n                  <\/jats:p>","DOI":"10.1111\/cge.14224","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T23:50:38Z","timestamp":1662594638000},"page":"3-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Genetic overview of postaxial polydactyly: Updated classification"],"prefix":"10.1111","volume":"103","author":[{"given":"Zaheer","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Biosciences COMSATS Institute of Information Technology  Islamabad 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