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In vivo fertilization occurs in the fallopian tube, where a specific and natural environment enables the embryo's healthy development. During this dynamic period, major waves of epigenetic reprogramming, crucial for the normal fate of the embryo, take place. Over the past decade, concerns relating to the raised incidence of epigenetic anomalies and imprinting following ART have been raised by several authors. Epigenetic reprogramming is particularly susceptible to environmental conditions during the periconceptional period; therefore, unphysiological conditions, including ovarian stimulation, in vitro fertilization, embryo culture, cryopreservation of gametes and embryos, parental lifestyle, and underlying infertility, have the potential to contribute to epigenetic dysregulation independently or collectively. This review critically appraises the evidence relating to the association between ART and genetic and epigenetic modifications that may be transmitted to the offspring.<\/jats:p>","DOI":"10.1111\/cge.14232","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T22:59:26Z","timestamp":1663282766000},"page":"133-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Risk of genetic and epigenetic alteration in children conceived following\n                    <scp>ART<\/scp>\n                    : Is it time to return to nature whenever possible?"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7698-8823","authenticated-orcid":false,"given":"Romualdo","family":"Sciorio","sequence":"first","affiliation":[{"name":"Edinburgh Assisted Conception Programme, EFREC Royal Infirmary of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Tramontano","sequence":"additional","affiliation":[{"name":"Department of Women, Infants and Adolescents, Division of Obstetrics Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Rapalini","sequence":"additional","affiliation":[{"name":"IVF Department Versilia Hospital Lido di Camaiore  Lucca Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Bellaminutti","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Ospedale Regionale di Lugano  Lugano Switzerland"},{"name":"Gynecology and Fertility Unit Procrea Institute  Lugano Switzerland"},{"name":"Gynecology Unit Centro Medico  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco M.","family":"Bulletti","sequence":"additional","affiliation":[{"name":"CHUV \u2013 Maternit\u00e9\/Gyn\u00e9cologie et Obst\u00e9trique  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"D'Amato","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Clinic University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Manna","sequence":"additional","affiliation":[{"name":"Biofertility IVF and Infertility Center  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Palagiano","sequence":"additional","affiliation":[{"name":"CFA Napoli, Italy CFA: Centro Fecondazione Assistita Napoli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Bulletti","sequence":"additional","affiliation":[{"name":"Ostetricia e Ginecologia EXTRA OMNES Medicina e Salute Riproduttiva  Cattolica Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-9680","authenticated-orcid":false,"given":"Sandro C.","family":"Esteves","sequence":"additional","affiliation":[{"name":"Andrology and Human Reproduction Clinic  Campinas Brazil"},{"name":"Department of Surgery (Division of Urology) University of Campinas (UNICAMP)  Campinas Brazil"},{"name":"Faculty of Health, Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa250"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92957-4"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12522-014-0183-3"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des197"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-015-0059-y"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr047"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa310"},{"issue":"3","key":"e_1_2_15_9_1","first-page":"e1","article-title":"Oocyte and Embryo manipulation and epigenetics","volume":"36","author":"Osman E","year":"2018","journal-title":"Semin Reprod Med"},{"key":"e_1_2_15_10_1","doi-asserted-by":"crossref","unstructured":"WaddingtonCH.The epigenotype.1942;1:18\u201020. 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