{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:47:01Z","timestamp":1788364021531,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Huntington Disease (HD) is an incurable autosomal dominant single gene neurodegenerative disorder. Typical onset is between 30 and 40\u2009years and characterised by motor difficulties, cognitive impairment, and behavioural and personality changes. The availability of reproductive testing means that affected and at\u2010risk individuals can make reproductive decisions with genetic risk in mind. We aimed to summarise the literature on reproductive decision\u2010making in the context of HD risk in terms of outcomes and the subjective experiences of at\u2010risk individuals. Five databases were searched. Findings were synthesised using Framework analysis to identify common factors across results of quantitative and qualitative studies. Twenty five studies met inclusion criteria. Framework analysis identified the following key areas: \u2018The relationship between reproductive intentions and HD genetic risk\u2019, \u2018Views on assistive options\u2019, \u2018Complexity and challenges in reproductive decision\u2010making\u2019, \u2018Actual reproductive outcomes\u2019, and \u2018Other factors influencing reproductive decision\u2010making\u2019. Quality of included studies was mixed. Reproductive decision making in the context of HD risk was found to be a complex and emotionally challenging process. Further research is required into reproductive decision\u2010making and outcomes among those not utilising assistive options, and in developing a model of reproductive decision\u2010making in HD.<\/jats:p>","DOI":"10.1111\/cge.14345","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:26:12Z","timestamp":1682382372000},"page":"147-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Genetic risk for Huntington Disease and reproductive decision\u2010making: A systematic review"],"prefix":"10.1111","volume":"104","author":[{"given":"Neil","family":"Fahy","sequence":"first","affiliation":[{"name":"ADAPT Lab, Research Department of Clinical Educational and Health Psychology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Rice","sequence":"additional","affiliation":[{"name":"ADAPT Lab, Research Department of Clinical Educational and Health Psychology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayana","family":"Lahiri","sequence":"additional","affiliation":[{"name":"St George's University Hospitals NHS Foundation Trust &amp; St Georges University of London, IMBE  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopal","family":"Desai","sequence":"additional","affiliation":[{"name":"ADAPT Lab, Research Department of Clinical Educational and Health Psychology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Stott","sequence":"additional","affiliation":[{"name":"ADAPT Lab, Research Department of Clinical Educational and Health Psychology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101172\u20105\u201040\/TABLES\/5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1039856218791036"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010381328\u20102.00013\u20104"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ENE.13413"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3174\/AJNR.A3772"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010381328\u20102.00014\u20106"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.8.2.141"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2016.1109630"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11136\u2010011\u20100062\u2010X\/TABLES\/1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.12740\/PP\/34496"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1602\/NEURORX.1.2.255\/METRICS"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1399\u20100004.2012.01900.X"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/HUMUPD\/DMS058"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2017.10.012"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/JEBM.12266"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12874\u2010017\u20100347\u2010Z\/TABLES\/4"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.N71"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/306234a0"},{"key":"e_1_2_10_20_1","volume-title":"Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields","author":"Kmet LM","year":"2004"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203413081_chapter_9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/JMG.33.9.737"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201774"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10897\u2010005\u20100619\u20103"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj\/ejhg\/5200781"},{"key":"e_1_2_10_26_1","unstructured":"FowlerAL.Psychological Ramifications of Presymptomatic Genetic Testing for Huntington's Disease: An Exploration of Coping the Partner Relationship and Reproductive Decision\u2010making. 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