{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:05:20Z","timestamp":1792461920554,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771052"],"award-info":[{"award-number":["81771052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974145"],"award-info":[{"award-number":["81974145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tooth eruption is an important and unique biological process during craniofacial development. Both the genetic and environmental factors can interfere with this process. Here we aimed to find the failure pattern of tooth eruption among five genetic diseases. Both systematic review and meta\u2010analysis were used to identify the genotype\u2013phenotype associations of unerupted teeth. The meta\u2010analysis was based on the characteristics of abnormal tooth eruption in 223 patients with the mutations in <jats:italic>PTH1R<\/jats:italic>, <jats:italic>RUNX2<\/jats:italic>, <jats:italic>COL1A1\/2<\/jats:italic>, <jats:italic>CLCN7<\/jats:italic>, and <jats:italic>FAM20A<\/jats:italic> respectively<jats:italic>.<\/jats:italic> We found all the patients presented selective failure of tooth eruption (SFTE). Primary failure of eruption patients with <jats:italic>PTH1R<\/jats:italic> mutations showed primary or isolated SFTE1 in the first and second molars (59.3% and 52% respectively). <jats:italic>RUNX2<\/jats:italic> related cleidocranial dysplasia usually had SFTE2 in canines and premolars, while <jats:italic>COL1A1\/2<\/jats:italic> related osteogenesis imperfecta mostly caused SFTE3 in the maxillary second molars (22.9%). In <jats:italic>CLCN7<\/jats:italic> related osteopetrosis, the second molars and mandibular first molars were the most affected. While <jats:italic>FAM20A<\/jats:italic> related enamel renal syndrome most caused SFTE5 in the second molars (86.2%) and maxillary canines. In conclusion, the SFTE was the common characteristics of most genetic diseases with abnormal isolated or syndromic tooth eruption. The selective pattern of unerupted teeth was gene\u2010dependent. Here we recommend SFTE to classify those genetic unerupted teeth and guide for precise molecular diagnosis and treatment.<\/jats:p>","DOI":"10.1111\/cge.14400","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T05:24:45Z","timestamp":1689312285000},"page":"287-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<scp>Genotype\u2010phenotype<\/scp> analysis of selective failure of tooth eruption\u2014A systematic review"],"prefix":"10.1111","volume":"104","author":[{"given":"Xinyue","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology Clinic of Oral Rare and Genetic Diseases, School of Stomatology, The Fourth Military Medical University  Xi'an People's Republic of 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