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We report a mother with Huntington's disease (HD) associated with motor neuron disease (MND) signs and her daughter suffering from ALS with subtle signs of HD, both carrying a pathogenic allele of the <jats:italic>HTT<\/jats:italic> gene (i.e., &gt;39 repeats). The co\u2010occurrence of MND and chorea has been reported in previous cases. Subjects showing both ALS and HD signs and carrying <jats:italic>HTT<\/jats:italic> pathogenic expansions in two generations of the same kindred have never been reported so far. The study of the overlap of disease mechanisms at the cellular level between TDP\u201043 and Huntingtin is relevant in an era offering promising strategies of targeted treatments in neurodegenerative disorders.<\/jats:p>","DOI":"10.1111\/cge.14472","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T05:32:52Z","timestamp":1702531972000},"page":"430-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A mother and her daughter carrying a pathogenic expansion of the <scp><i>HTT<\/i><\/scp> gene with a phenotype encompassing motor neuron disease and <scp>Huntington's<\/scp> disease"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5876-4079","authenticated-orcid":false,"given":"Antonio","family":"Canosa","sequence":"first","affiliation":[{"name":"ALS Centre, \u2018Rita Levi Montalcini\u2019 Department of Neuroscience University of Turin  Turin 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