{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T18:41:02Z","timestamp":1774723262468,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Beckwith\u2013Wiedemann syndrome (BWS) is an epigenetic overgrowth syndrome. Despite its distinctive growth pattern, the detailed growth trajectories of children with BWS remain largely unknown. We retrospectively analyzed 413 anthropometric measurements over an average of 4.4\u2009years of follow\u2010up in 51 children with BWS. We constructed sex\u2010specific percentile curves for height, weight, and head circumference using a generalized additive model for location, scale, and shape. Males with BWS exhibited greater height at all ages evaluated, weight before the age of 10, and head circumference before the age of 9 than those of the general population. Females with BWS showed greater height before the age of 7, weight before the age of 4.5, and head circumference before the age of 7 than those of the general population. At the latest follow\u2010up visit at a mean 8.4\u2009years of age, bone age was significantly higher than chronological age. Compared to paternal uniparental disomy (pUPD), males with imprinting center region 2\u2010loss of methylation (IC2\u2010LOM) had higher standard deviation score (SDS) for height and weight, while females with IC2\u2010LOM showed larger SDS for head circumference. These disease\u2010specific growth charts can serve as valuable tools for clinical monitoring of children with BWS.<\/jats:p>","DOI":"10.1111\/cge.14488","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T07:19:57Z","timestamp":1706080797000},"page":"533-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Development of disease\u2010specific growth charts for Korean children with\n                    <scp>Beckwith\u2013Wiedemann<\/scp>\n                    syndrome"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2966-9608","authenticated-orcid":false,"given":"Naye","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Seoul National University Children's Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-5315","authenticated-orcid":false,"given":"Hwa Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Bundang Hospital  Seongnam\u2010Si South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0407-7828","authenticated-orcid":false,"given":"Jung Min","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Children's Hospital  Seoul South Korea"},{"name":"Department of Pediatrics Seoul National University College of Medicine  Seoul South Korea"},{"name":"Rare Disease Center Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36080"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.88"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.166"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30267"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2022.42.6.668"},{"issue":"12","key":"e_1_2_9_7_1","article-title":"Guided growth in leg length discrepancy in Beckwith\u2010Wiedemann syndrome: a consecutive case series","volume":"8","author":"De Pellegrin M","year":"2021","journal-title":"Children (Basel)"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.01.020"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12759"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355544"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12635"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37801"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00562"},{"key":"e_1_2_9_14_1","unstructured":"ShumanC KalishJM WeksbergR.Beckwith\u2010Wiedemann syndrome. 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