{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:18Z","timestamp":1772160078337,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cancers are genetically categorized into common diseases showing a so\u2010called multifactorial inheritance except for rare familial cancers. And as a measure to estimate the strength of genetic factors in the multifactorial diseases, heritability (\n                    <jats:italic>h<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    )\u00a0is generally used. However, there have been few reports on the estimation of heritability for cancers. We calculated the heritability from the incidence in subject population and the familial recurrence rate in first\u2010degree relatives of the affected for cancers quoting the data from a large\u2010scale prospective cohort study by Hidaka et al. published in 2020. This is the first report for heritability of any cancers in Japanese population. The results showed that heritability of overall cancers in Japanese population is 0.064, which is much lower than Nordic population reported by Mucci et al. that was 0.33. For individual cancers, stomach cancer (\n                    <jats:italic>h<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.14), colorectum cancer (0.006), lung cancer (0.08) and uterine cancer (0.16) accounted for half of the total patients, and each heritability tends to be lower than previously reported for the European descent. The results of this study suggest that heritability of cancers varies greatly by ethnicity. And these results should be important in terms of cancer genetics and in the genetic counseling for cancers.\n                  <\/jats:p>","DOI":"10.1111\/cge.14535","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T02:39:43Z","timestamp":1714444783000},"page":"204-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heritability of cancers in Japanese population: Estimation from recent cohort data"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8085-5919","authenticated-orcid":false,"given":"Yoshiro","family":"Nagao","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics Tokai University Hospital  Isehara Kanagawa Japan"},{"name":"Department of Laboratory Examination Takashimadaira Chuo General Hospital  Itabashi Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Tokai University Hospital  Isehara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"National Cancer Center Cancer Information Service.Cancer Statistics.https:\/\/ganjoho.jp\/reg_stat\/index.html"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.022731"},{"key":"e_1_2_9_4_1","first-page":"29","article-title":"Estimating trait heritability","volume":"1","author":"Wray N","year":"2008","journal-title":"Nat 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K","year":"2005","journal-title":"J Health Welfare Stat"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2022.08.007"},{"issue":"1","key":"e_1_2_9_15_1","first-page":"15","article-title":"Epidemiology of bladder cancer","volume":"8","author":"Saginala K","year":"2020","journal-title":"Med Sci"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2015.01.014"}],"container-title":["Clinical 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