{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:17Z","timestamp":1772160077536,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171154"],"award-info":[{"award-number":["82171154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873705"],"award-info":[{"award-number":["81873705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    With the development of the social economy, we are exposed to increasing noise in our daily lives. Our previous work found an ABCC1(NM_004996.3:c.A1769G, NP_004987.2:p.N590S) variant which cosegregated with the patients in an autosomal dominant non\u2010syndromic hearing loss family. At present, the specific mechanism of deafness caused by ABCC1 mutation is still not clear. Using the knock\u2010in mouse model simulating human ABCC1 mutation, we found that the occurrence of family\u2010related phenotypes was likely attributed to the combination of the mouse genotype and low\u2010intensity noise. GSH and GSSG are important physiological substrates of ABCC1. The destruction of GSH\u2010GSSG balance in the cochleae of both Abcc1\n                    <jats:sup>N591S\/+<\/jats:sup>\n                    mice and Abcc1\n                    <jats:sup>N591S\/N591S<\/jats:sup>\n                    mice during low\u2010intensity noise exposure may result in irreversible damage to the hair cells of the cochleae, consequently leading to hearing loss in mice. The findings offered a potential novel idea for the prevention and management of hereditary hearing loss within this family.\n                  <\/jats:p>","DOI":"10.1111\/cge.14582","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:19:35Z","timestamp":1719879575000},"page":"462-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low\u2010intensity noise exposure takes an essential part in the mechanism of late\u2010onset hereditary hearing loss caused by Abcc1 mutation"],"prefix":"10.1111","volume":"106","author":[{"given":"Mengzhu","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders (Xiangya Hospital)  Hunan Changsha China"},{"name":"Department of Otolaryngology Fujian Medical University Union Hospital  Fuzhou Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders (Xiangya Hospital)  Hunan Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha Hunan 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