{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:23Z","timestamp":1772160083147,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Familial non\u2010medullary thyroid cancer, defined as two or more affected first\u2010degree relatives, accounts for 3%\u20139% of thyroid cancers. It is associated with more aggressive cancer, early age at diagnosis, multifocality, and increased risk of metastasis and recurrence. Although no high penetrance predisposing gene has been identified at present, the estimated contribution of genetics is significant. Our study explored five families presenting FNMTC using Whole\u2010Exome Sequencing and found three candidate genes:\n                    <jats:italic>TELO2<\/jats:italic>\n                    in one family,\n                    <jats:italic>UACA<\/jats:italic>\n                    and\n                    <jats:italic>BCL2L11<\/jats:italic>\n                    in another. All of these tumor suppressor genes are expressed in the thyroid, exhibit under\u2010expression in tumor tissue compared to healthy tissue both in silico and in our samples, and two of them are known to be involved in thyroid carcinogenesis via the FOXO3A pathway. Functional analysis to validate these candidate genes in thyroid cancer cells showed that one of the three,\n                    <jats:italic>BCL2L11<\/jats:italic>\n                    , has a tumor suppressor effect on proliferation and apoptosis. Their impact on hereditary predisposition to thyroid cancer, as well as their combined effects, requires further study. Indeed, a case\u2013control study would be essential to determine the diagnostic utility of their routine analysis.\n                  <\/jats:p>","DOI":"10.1111\/cge.70060","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T05:35:05Z","timestamp":1756964105000},"page":"458-469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of\n                    <scp>\n                      <i>BCL2L11<\/i>\n                    <\/scp>\n                    as a Candidate Gene for Hereditary Predisposition to Non\u2010Medullary Thyroid Cancer Using Familial Whole\u2010Exome\u2010Sequencing"],"prefix":"10.1111","volume":"109","author":[{"given":"Duygu","family":"Abbasoglu","sequence":"first","affiliation":[{"name":"D\u00e9partement d'Oncog\u00e9n\u00e9tique Centre Jean Perrin  Clermont\u2010Ferrand France"},{"name":"U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques Universit\u00e9 Clermont Auvergne, INSERM  Clermont Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathis","family":"Lepage","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Oncog\u00e9n\u00e9tique Centre Jean Perrin  Clermont\u2010Ferrand France"},{"name":"U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques Universit\u00e9 Clermont Auvergne, INSERM  Clermont Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Sonnier","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Oncog\u00e9n\u00e9tique Centre Jean Perrin  Clermont\u2010Ferrand France"},{"name":"U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques Universit\u00e9 Clermont Auvergne, INSERM  Clermont Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Viala","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Oncog\u00e9n\u00e9tique Centre Jean Perrin  Clermont\u2010Ferrand France"},{"name":"U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques Universit\u00e9 Clermont Auvergne, INSERM  Clermont Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Uhrhammer","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Oncog\u00e9n\u00e9tique Centre Jean Perrin  Clermont\u2010Ferrand France"},{"name":"U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques Universit\u00e9 Clermont Auvergne, INSERM  Clermont Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flora","family":"Ponelle\u2010Chachuat","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Oncog\u00e9n\u00e9tique Centre Jean Perrin  Clermont\u2010Ferrand France"},{"name":"U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques Universit\u00e9 Clermont Auvergne, INSERM  Clermont Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Cayre","sequence":"additional","affiliation":[{"name":"U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques Universit\u00e9 Clermont Auvergne, INSERM  Clermont Ferrand France"},{"name":"D\u00e9partement de Pathologie Centre Jean Perrin  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maud","family":"Privat","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Oncog\u00e9n\u00e9tique Centre Jean Perrin  Clermont\u2010Ferrand France"},{"name":"U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques Universit\u00e9 Clermont Auvergne, INSERM  Clermont Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Cavaill\u00e9","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Oncog\u00e9n\u00e9tique Centre Jean Perrin  Clermont\u2010Ferrand France"},{"name":"U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques Universit\u00e9 Clermont Auvergne, INSERM  Clermont Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"Bidet","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Oncog\u00e9n\u00e9tique Centre Jean Perrin  Clermont\u2010Ferrand France"},{"name":"U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques Universit\u00e9 Clermont Auvergne, INSERM  Clermont Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"J.Ferlay M.Ervik F.Lam et\u00a0al. \u201cGlobal Cancer Observatory: Cancer Today. 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