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The authors investigated the distribution of amino terminal pro\u2010brain natriuretic peptide (NT\u2010proBNP) between hematologic and solid organ malignancies and the relationship of NT\u2010proBNP with volume status in oncologic patients. A total of 145 consecutive patients with at least one occurrence of NT\u2010proBNP exceeding the upper normal range 10\u2010fold were identified. The authors retrospectively reviewed their records including clinical, laboratory, and radiological data and echocardiograms. More than 70% of patients had hematologic malignancies. Patients with NT\u2010proBNP &gt;50,000\u00a0pg\/mL had only hematologic malignancies, primarily multiple myeloma. There was no association between M\u2010spike proteins and NT\u2010proBNP. About 80% of patients had signs of fluid overload. The magnitude of NT\u2010proBNP elevation was similar between those with and without heart failure or volume overload, as well as with solid cancers vs hematologic malignancies. Contrary to prior reports, it was found that very high NT\u2010proBNP in cancer patients is usually encountered in the context of fluid overload and most often in hematologic malignancies.<\/jats:p>","DOI":"10.1111\/chf.12018","type":"journal-article","created":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T09:29:15Z","timestamp":1356686955000},"page":"143-148","source":"Crossref","is-referenced-by-count":32,"title":["What Is Causing Extremely Elevated Amino Terminal Brain Natriuretic Peptide in Cancer Patients?"],"prefix":"10.1111","volume":"19","author":[{"given":"Jesal","family":"Popat","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of South Florida and Moffitt Cancer Center Tampa FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abel","family":"Rivero","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of South Florida and Moffitt Cancer Center Tampa 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