{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:02:48Z","timestamp":1769119368459,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T00:00:00Z","timestamp":1358726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congestive Heart Failure"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Despite the widespread use of loop diuretics to treat acute decompensated heart failure (<jats:styled-content style=\"fixed-case\">ADHF<\/jats:styled-content>), robust data supporting their role and optimal dosing strategies are scarce. This analysis aimed to compare clinical outcomes of patients admitted with <jats:styled-content style=\"fixed-case\">ADHF<\/jats:styled-content> who received a diuretic dosing protocol with those who received the usual diuretic therapy. We performed an observational medical records review to compare the use of a nurse\u2010driven diuretic dosing protocol with usual diuretic dosing for patients admitted with <jats:styled-content style=\"fixed-case\">ADHF<\/jats:styled-content> during a 1\u2010year period. Using a propensity scoring model, comparisons were made between groups for total weight loss, length of stay (<jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>), 30\u2010day readmissions, in\u2010hospital mortality, 30\u2010day mortality, and acute kidney failure. Sixty\u2010eight of the 596 patients admitted with <jats:styled-content style=\"fixed-case\">ADHF<\/jats:styled-content> during the study period received the diuretic protocol. Protocol use was associated with an additional 2.63\u2010kg weight loss (<jats:italic>P<\/jats:italic>=.003) but a trend toward increased <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content> compared with patients receiving usual care (<jats:italic>P<\/jats:italic>=.097). However, patients receiving the protocol had a significantly lower risk of 30\u2010day readmission (<jats:styled-content style=\"fixed-case\">odds ratio,<\/jats:styled-content> 0.46, 95% <jats:styled-content style=\"fixed-case\">confidence interval,<\/jats:styled-content> 0.22\u20130.95). Protocol use was not associated with significant differences in kidney failure, inpatient mortality, or 30\u2010day mortality. A diuretic dosing protocol for patients admitted with <jats:styled-content style=\"fixed-case\">ADHF<\/jats:styled-content> improves weight loss and may lower 30\u2010day readmissions, at the cost of potentially increasing <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/chf.12020","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T05:05:12Z","timestamp":1358831112000},"page":"53-60","source":"Crossref","is-referenced-by-count":20,"title":["A Diuretic Protocol Increases Volume Removal and Reduces Readmissions Among Hospitalized Patients With Acute Decompensated Heart Failure"],"prefix":"10.1111","volume":"19","author":[{"given":"Jeffrey H.","family":"Barsuk","sequence":"first","affiliation":[{"name":"Division of Hospital Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Division of Cardiology Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine R.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of Hospital Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Cotts","sequence":"additional","affiliation":[{"name":"Division of Cardiology Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Malkenson","sequence":"additional","affiliation":[{"name":"Division of Hospital Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clyde W.","family":"Yancy","sequence":"additional","affiliation":[{"name":"Division of Cardiology Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark V.","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Hospital Medicine Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.041"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.10.1240"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.072"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.08.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.022"},{"key":"e_1_2_8_7_1","unstructured":"FDA Approved Drug Products.http:\/\/www.accessdata.fda.gov\/scripts\/cder\/drugsatfda\/index.cfm?fuseaction=Search.DrugDetails. 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