{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:37:08Z","timestamp":1782625028162,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T00:00:00Z","timestamp":1365984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congestive Heart Failure"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Resynchronization therapy has become standard of care in patients with left bundle branch block (LBBB<\/jats:styled-content>), congestive heart failure (CHF<\/jats:styled-content>), and low ejection fraction (EF<\/jats:styled-content>). In order to characterize the left ventricular (LV)<\/jats:styled-content> function evolution in patients with LBBB<\/jats:styled-content> and baseline preserved LVEF<\/jats:styled-content>, records of all patients who visited an academic echocardiography laboratory during a period of 4 years were retrospectively investigated. Patients were included if they had a baseline EF<\/jats:styled-content> >50%, LBBB<\/jats:styled-content> on surface electrocardiography, and at least one follow\u2010up echocardiogram no earlier than 3 months after the baseline study. The endpoint was the occurrence of EF<\/jats:styled-content> deterioration to values \u226440%. Clinical variables associated with this outcome were identified. Forty\u2010nine patients satisfied the entry criteria. Over a mean 13\u00b18.5 months of follow\u2010up (range 3 to 36), 8 patients (16%) experienced EF<\/jats:styled-content> deterioration \u226440%. History of CHF<\/jats:styled-content> prior to baseline echocardiogram and LV<\/jats:styled-content> mass >300 g were associated with this phenomenon (P<\/jats:italic>=.004 and P<\/jats:italic>=.015, respectively), with a negative predictive value of 100% and 92%, respectively. Our data profiles a risk\u2010stratification methodology in patients with LBBB<\/jats:styled-content> and baseline EF<\/jats:styled-content> >50% and possibly a triage strategy toward resynchronization therapy in this population.<\/jats:p>","DOI":"10.1111\/chf.12028","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T02:58:09Z","timestamp":1366081089000},"source":"Crossref","is-referenced-by-count":11,"title":["Predictors of Left Ventricular Function Deterioration in Patients With Left Bundle Branch Block and Ejection Fraction >50%"],"prefix":"10.1111","volume":"19","author":[{"given":"George O.","family":"Angheloiu","sequence":"first","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA"},{"name":"Dubois Regional Medical Center Dubois PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Saul","sequence":"additional","affiliation":[{"name":"Clinical Research Informatics Service University of Pittsburgh Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Edelman","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemal","family":"Shah","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ure L.","family":"Mezu","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Saba","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7133.2008.07827.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.06.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90771-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc1102.105289"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.08.045"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.64.4.744"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.4.845"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.11.064"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907555"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eupc.2005.06.005"}],"container-title":["Congestive Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fchf.12028","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/chf.12028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:28:01Z","timestamp":1696336081000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/chf.12028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,15]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/chf.12028"],"URL":"https:\/\/doi.org\/10.1111\/chf.12028","archive":["Portico"],"relation":{},"ISSN":["1527-5299","1751-7133"],"issn-type":[{"value":"1527-5299","type":"print"},{"value":"1751-7133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,15]]}}}