{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T02:43:02Z","timestamp":1774320182473,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congestive Heart Failure"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>A systematic review of the literature was performed by searching Pubmed and <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> databases using the terms \u201cthiamine,\u201d \u201cvitamin B1,\u201d \u201cheart failure,\u201d \u201csystolic dysfunction,\u201d \u201cventricular dysfunction,\u201d \u201ccardiomyopathy,\u201d \u201cventricular failure,\u201d and \u201csystolic failure.\u201d Relevant trials and articles were evaluated pertaining to thiamine deficiency in patients with heart failure (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>) and references were searched for further inclusion of articles. A total of 20 articles were reviewed and summarized in detail. While more research is needed to fully elucidate the clinical thiamine deficiency in <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> patients, recent evidence has indicated that supplementing with thiamine in <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> patients has the potential to improve left ventricular ejection fraction. Thiamine deficiency appears to be not uncommon in patients with <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>, and supplementation with thiamine has been shown to improve cardiac function, urine output, weight loss, and signs and symptoms of <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>. Therefore, this simple therapy should be tested in large\u2010scale randomized clinical trial to further determine the effects of thiamine in <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/chf.12037","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T10:39:51Z","timestamp":1375439991000},"page":"214-222","source":"Crossref","is-referenced-by-count":84,"title":["Thiamine Supplementation for the Treatment of Heart Failure: A Review of the Literature"],"prefix":"10.1111","volume":"19","author":[{"given":"James J.","family":"DiNicolantonio","sequence":"first","affiliation":[{"name":"Wegmans Pharmacy Ithaca NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asfandyar K.","family":"Niazi","sequence":"additional","affiliation":[{"name":"Shifa College of Medicine Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl J.","family":"Lavie","sequence":"additional","affiliation":[{"name":"John Ochsner Heart and Vascular Institute Ochsner Clinical School The University of Queensland School of Medicine New Orleans LA"},{"name":"Pennington Biomedical Research Center Baton Rouge LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"O'Keefe","sequence":"additional","affiliation":[{"name":"Mid America Heart Institute at Saint Luke's Hospital University of Missouri Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector O.","family":"Ventura","sequence":"additional","affiliation":[{"name":"John Ochsner Heart and Vascular Institute Ochsner Clinical School The University of Queensland School of Medicine New Orleans LA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8]]},"reference":[{"key":"e_1_2_17_2_1","volume-title":"Heart Disease and Stroke Statistics: 2005 Update","author":"American Heart Association","year":"2005"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.012"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(97)70173-X"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533608323430"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90121-0"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-5299.2007.06260.x"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-006-9195-3"},{"key":"e_1_2_17_9_1","first-page":"59","article-title":"Thiamine. 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