{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T02:37:58Z","timestamp":1768531078588,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Osteonecrosis of the jaws in patients treated with bisphosphonates is mostly associated with intravenous bisphosphonates while the incidence associated with oral bisphosphonates is not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this paper is to describe a series of cases of jaw osteonecrosis that may be associated with dental implant placement in patients who had taken nitrogen containing bisphosphonates via oral and\/or intravenous route.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Six female patients were treated for osteonecrosis of the jaw after implant placement. An average age was 71.8\u2009\u00b1\u20096.5 years old and they had a history of bisphosphonate use. Two patients suffered from cancer and the other patients had osteoporosis. Two osteoporosis patients had taken only oral bisphosphonate and the other patients received intravenous bisphosphonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Resection of necrotized bone, implant removal, and primary closure were performed in five patients and four patients showed uneventful healing. One patient presented recurrence at the maxilla and underwent further extraction and resection. One patient presented with an exposure of the bone after implant placement was treated with an advanced flap closure, and the implants were preserved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Unusual jaw necrosis after dental implant surgery might be related with oral and\/or intravenous bisphosphonates. Wide resection of necrotic bone, collagen graft, and primary closure are key factors for successful healing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12048","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T16:27:40Z","timestamp":1361982460000},"page":"751-761","source":"Crossref","is-referenced-by-count":29,"title":["Osteonecrosis of the Jaw after Implant Surgery in Patients Treated with Bisphosphonates \u2013 A Presentation of Six Consecutive Cases"],"prefix":"10.1111","volume":"16","author":[{"given":"Yvonne","family":"Tam","sequence":"first","affiliation":[{"name":"Private practice  Vallejo CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kian","family":"Kar","sequence":"additional","affiliation":[{"name":"Department of Advanced Periodontics University of Southern California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hessam","family":"Nowzari","sequence":"additional","affiliation":[{"name":"Private practice  Beverly Hills CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Suk","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics College of Medicine Asan Medical Center University of Ulsan  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang\u2010Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery College of Medicine Asan Medical Center University of Ulsan  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.99.132"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080205"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01772.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.10.061"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2009.0019"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.11.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.07.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2010.02.037"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00181.x"},{"key":"e_1_2_7_12_1","first-page":"349","article-title":"Safety of oral bisphosphonates: controlled studies on alveolar bone","volume":"21","author":"Jeffcoat MK","year":"2006","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.12.040"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.09.019"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2010.04.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2012.09.012"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.100471"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4477.2009.00213.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.01.009"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2006.05.002"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012003189.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2010.05.043"}],"container-title":["Clinical Implant Dentistry and Related Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcid.12048","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cid.12048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:56:17Z","timestamp":1696352177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cid.12048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,27]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/cid.12048"],"URL":"https:\/\/doi.org\/10.1111\/cid.12048","archive":["Portico"],"relation":{},"ISSN":["1523-0899","1708-8208"],"issn-type":[{"value":"1523-0899","type":"print"},{"value":"1708-8208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,27]]}}}