{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:14:06Z","timestamp":1783120446532,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":839,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Implant Dentistry and Related Research"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1111\/cid.12083","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T17:09:47Z","timestamp":1368637787000},"page":"199-207","source":"Crossref","is-referenced-by-count":38,"title":["Periodontopathogen and Epstein-Barr Virus-Associated Periapical Periodontitis May Be the Source of Retrograde Infectious Peri-Implantitis"],"prefix":"10.1111","volume":"17","author":[{"given":"Fernando","family":"Verdugo","sequence":"first","affiliation":[{"name":"Periodontics Department; VA Hospital Greater Los Angeles Healthcare System; Los Angeles CA USA"},{"name":"private practice; Altadena CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Microbiology; School of Medicine; University of Granada; Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krikor","family":"Simonian","sequence":"additional","affiliation":[{"name":"Department of Periodontics\/Advanced Periodontology; University of Southern California School of Dentistry; Los Angeles CA USA"},{"name":"private practice; Pasadena CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Microbiology; School of Dentistry; University of Granada; Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Farez-Vidal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Molecular Biology; University of Granada; School of Medicine; Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"D'Addona","sequence":"additional","affiliation":[{"name":"Odontology Clinic; Catholic University Sacro Cuore; Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"10.1111\/cid.12083-BIB0001|cid12083-cit-0001","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1600-0765.2004.00728.x","article-title":"Herpesviral-bacterial interrelationships in aggressive periodontitis","volume":"39","author":"Saygun","year":"2004","journal-title":"J Periodontal Res"},{"key":"10.1111\/cid.12083-BIB0002|cid12083-cit-0002","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1600-0757.2005.00145.x","article-title":"Host-mediated resolution of inflammation in periodontal diseases","volume":"40","author":"Kantarci","year":"2006","journal-title":"Periodontol 2000"},{"key":"10.1111\/cid.12083-BIB0003|cid12083-cit-0003","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1600-0757.2009.00308.x","article-title":"Herpesviral-bacterial interactions in periodontal diseases","volume":"52","author":"Slots","year":"2010","journal-title":"Periodontol 2000"},{"key":"10.1111\/cid.12083-BIB0004|cid12083-cit-0004","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1600-051X.2008.01301.x","article-title":"Human herpesvirus 7, Epstein-Barr virus and human cytomegalovirus in periodontal tissues of periodontally diseased and healthy subjects","volume":"35","author":"Rotola","year":"2008","journal-title":"J Clin Periodontol"},{"key":"10.1111\/cid.12083-BIB0005|cid12083-cit-0005","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.joen.2010.06.008","article-title":"Prevalence and activity of Epstein-Barr virus and human cytomegalovirus in symptomatic and asymptomatic apical periodontitis lesions","volume":"36","author":"Hern\u00e1di","year":"2010","journal-title":"J Endod"},{"key":"10.1111\/cid.12083-BIB0006|cid12083-cit-0006","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1600-0765.2006.00865.x","article-title":"Epstein-Barr virus in oral diseases","volume":"41","author":"Slots","year":"2006","journal-title":"J Periodontal Res"},{"key":"10.1111\/cid.12083-BIB0007|cid12083-cit-0007","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1902\/jop.2011.110086","article-title":"Periodontopathogen and Epstein-Barr virus contamination affects transplanted bone volume in sinus augmentation","volume":"83","author":"Verdugo","year":"2012","journal-title":"J Periodontol"},{"key":"10.1111\/cid.12083-BIB0008|cid12083-cit-0008","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.virusres.2006.02.008","article-title":"Epstein-Barr virus immunossuppression of innate immunity mediated by phagocytes","volume":"119","author":"Savard","year":"2006","journal-title":"Virus Res"},{"key":"10.1111\/cid.12083-BIB0009|cid12083-cit-0009","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.semcancer.2008.10.008","article-title":"Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products","volume":"18","author":"Ressing","year":"2008","journal-title":"Semin Cancer Biol"},{"key":"10.1111\/cid.12083-BIB0010|cid12083-cit-0010","first-page":"2603","volume-title":"Fields virology","author":"Kieff","year":"2007"},{"key":"10.1111\/cid.12083-BIB0011|cid12083-cit-0011","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nm0602-594","article-title":"Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus","volume":"8","author":"Borza","year":"2002","journal-title":"Nat Med"},{"key":"10.1111\/cid.12083-BIB0012|cid12083-cit-0012","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1600-0765.2010.01335.x","article-title":"Salivary infectious agents and periodontal disease status","volume":"46","author":"Saygun","year":"2011","journal-title":"J Periodontal Res"},{"key":"10.1111\/cid.12083-BIB0013|cid12083-cit-0013","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1034\/j.1399-302X.2003.00079.x","article-title":"Cytomegalovirus and Epstein-Barr virus are associated with symptomatic periapical pathosis","volume":"18","author":"Sabeti","year":"2003","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/cid.12083-BIB0014|cid12083-cit-0014","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00004770-200402000-00001","article-title":"Herpesviral-bacterial coinfection in periapical pathosis","volume":"30","author":"Sabeti","year":"2004","journal-title":"J Endod"},{"key":"10.1111\/cid.12083-BIB0015|cid12083-cit-0015","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1399-302X.2007.00362.x","article-title":"Herpesviruses in asymptomatic apical periodontitis lesions: an immunohistochemical approach","volume":"22","author":"Saboia-Dantas","year":"2007","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/cid.12083-BIB0016|cid12083-cit-0016","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s10266-011-0053-y","article-title":"Symptomatic and asymptomatic apical periodontitis associated with red complex bacteria: clinical and microbiological evaluation","volume":"101","author":"Buonavoglia","year":"2013","journal-title":"Odontology"},{"key":"10.1111\/cid.12083-BIB0017|cid12083-cit-0017","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1902\/jop.2011.110063","article-title":"Detection and clonal analysis of anaerobic bacteria associated to endodontic-periodontal lesions","volume":"82","author":"Pereira","year":"2011","journal-title":"J Periodontol"},{"key":"10.1111\/cid.12083-BIB0018|cid12083-cit-0018","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.joen.2012.06.037","article-title":"Bacterial flora of dental periradicular lesions analyzed by the 454-pyrosequencing technology","volume":"38","author":"Saber","year":"2012","journal-title":"J Endod"},{"key":"10.1111\/cid.12083-BIB0019|cid12083-cit-0019","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/jcpe.12045","article-title":"Aetiology, microbiology and therapy of periapical lesions around oral implants: a retrospective analysis","volume":"40","author":"Lefever","year":"2013","journal-title":"J Clin Periodontol"},{"key":"10.1111\/cid.12083-BIB0020|cid12083-cit-0020","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1034\/j.1600-0501.2002.130102.x","article-title":"The effects of an immediately pre-surgical chlorhexidine oral rinse on the bacterial contaminants of bone debris collected during dental implant surgery","volume":"13","author":"Young","year":"2002","journal-title":"Clin Oral Implants Res"},{"key":"10.1111\/cid.12083-BIB0021|cid12083-cit-0021","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1399-302X.2009.00540.x","article-title":"Cytomegalovirus-infected inflammatory cells in dental apical lesions","volume":"24","author":"Sabeti","year":"2009","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/cid.12083-BIB0022|cid12083-cit-0022","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1399-302X.1996.tb00180.x","article-title":"Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions","volume":"11","author":"Ashimoto","year":"1996","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/cid.12083-BIB0023|cid12083-cit-0023","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1177\/0022034510370026","article-title":"Analyzing endodontic infections by deep coverage pyrosequencing","volume":"89","author":"Li","year":"2010","journal-title":"J Dent Res"},{"key":"10.1111\/cid.12083-BIB0024|cid12083-cit-0024","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.joen.2011.08.012","article-title":"Pyrosequencing analysis of the apical root canal microbiota","volume":"37","author":"Siqueira","year":"2011","journal-title":"J Endod"},{"key":"10.1111\/cid.12083-BIB0025|cid12083-cit-0025","doi-asserted-by":"crossref","first-page":"e1001256","DOI":"10.1371\/journal.ppat.1001256","article-title":"HCMV spread and cell tropism are determined by distinct virus populations","volume":"7","author":"Scrivano","year":"2011","journal-title":"Plos Pathog"},{"key":"10.1111\/cid.12083-BIB0026|cid12083-cit-0026","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1160\/TH09-04-0213","article-title":"Endothelial cells in human cytomegalovirus infection: one host cell out of many or a crucial target for virus spread?","volume":"102","author":"Adler","year":"2009","journal-title":"Thromb Haemost"},{"key":"10.1111\/cid.12083-BIB0027|cid12083-cit-0027","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1056\/NEJM199806113382407","article-title":"Infection in organ-transplant recipients","volume":"338","author":"Fishman","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1111\/cid.12083-BIB0028|cid12083-cit-0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1000496","article-title":"The dynamics of EBV shedding implicate a central role for epithelial cells in amplifying viral output","volume":"5","author":"Hadinoto","year":"2009","journal-title":"Plos Pathog"},{"key":"10.1111\/cid.12083-BIB0029|cid12083-cit-0029","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2334\/josnusd.46.203","article-title":"Relationship between Porphyromonas gingivalis, Epstein-Barr virus infection and reactivation in periodontitis","volume":"46","author":"Sugano","year":"2004","journal-title":"J Oral Sci"},{"key":"10.1111\/cid.12083-BIB0030|cid12083-cit-0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/mus.10287","article-title":"Leukocytoclastic-vasculitic neuropathy associated with chronic Epstein-Barr virus infection","volume":"27","author":"Kanai","year":"2003","journal-title":"Muscle Nerve"},{"key":"10.1111\/cid.12083-BIB0031|cid12083-cit-0031","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1399-302X.2008.00471.x","article-title":"Relationship between human cytomegalovirus transcription and symptomatic apical periodontitis in Iran","volume":"23","author":"Yazdi","year":"2008","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/cid.12083-BIB0032|cid12083-cit-0032","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1600-0501.2005.01147.x","article-title":"Predisposing conditions for retrograde peri-implantitis, and treatment suggestions","volume":"16","author":"Quirynen","year":"2005","journal-title":"Clin Oral Implants Res"},{"key":"10.1111\/cid.12083-BIB0033|cid12083-cit-0033","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/j.1600-0501.2009.01752.x","article-title":"Endodontic treatment of teeth induces retrograde peri-implantitis","volume":"20","author":"Zhou","year":"2009","journal-title":"Clin Oral Implants Res"},{"key":"10.1111\/cid.12083-BIB0034|cid12083-cit-0034","first-page":"412","article-title":"Development and treatment of retrograde peri-implantitis involving a site with a history of failed endodontic and apicoectomy procedures: a series of reports","volume":"16","author":"Ayangco","year":"2001","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1111\/cid.12083-BIB0035|cid12083-cit-0035","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jcv.2008.01.007","article-title":"Patient with severe periodontitis and subgingival Epstein-Barr virus treated with antiviral therapy","volume":"42","author":"Sunde","year":"2008","journal-title":"J Clin Virol"},{"key":"10.1111\/cid.12083-BIB0036|cid12083-cit-0036","doi-asserted-by":"crossref","first-page":"11304","DOI":"10.1128\/JVI.74.23.11304-11310.2000","article-title":"Ongoing viral replication is required for gammaherpesvirus 68-induced vascular damage","volume":"74","author":"Dal Canto","year":"2000","journal-title":"J Virol"}],"container-title":["Clinical Implant Dentistry and Related Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcid.12083","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T13:43:46Z","timestamp":1625406226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cid.12083"}},"subtitle":["EBV-Associated Periapical Periodontitis"],"short-title":[],"issued":{"date-parts":[[2013,5,15]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"URL":"https:\/\/doi.org\/10.1111\/cid.12083","relation":{},"ISSN":["1523-0899"],"issn-type":[{"value":"1523-0899","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5,15]]}}}