{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:06:51Z","timestamp":1783102011094,"version":"3.54.6"},"reference-count":33,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T00:00:00Z","timestamp":1377475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study is a histopathological analysis of lesions clinically diagnosed as peri\u2010implantitis (PI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This retrospective study included microscopic findings in 117 peri\u2010implant biopsies from lesions presenting clinical and radiographic features of peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group included 117 biopsies, mean age 55.2 years; 60.9% of biopsies were from failing implants during explantation, the remaining from surviving implants. All cases showed microscopic evidence for inflammation; however, although 41% exhibited only nonspecific inflammation, 29.9% exhibited actinomyces\u2010related inflammation, 18.8% pyogenic granuloma (<jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>), and 10.3% giant cell granuloma (<jats:styled-content style=\"fixed-case\">GCG<\/jats:styled-content>). Differences in implant failure rates between pathological diagnostic groups were not statistically significant. Lesions with simple inflammation could not be distinguished clinically or radiographically from the potentially destructive lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There were no clinical features which could distinguish <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> with simple inflammation from potentially destructive lesions mimicking <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>, such as <jats:styled-content style=\"fixed-case\">GCG<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>, and actinomycosis. However, to control <jats:styled-content style=\"fixed-case\">GCG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> surgical procedures would be recommended, actinomycosis would indicate specific antibiotics, whereas in nonspecific inflammation, these measures may not be indicated. The results of the present study provide evidence for the importance of early microscopic examination of lesions presenting clinically as peri\u2010implantitis, a step toward more accurate diagnosis and improved treatment of <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> and lesions mimicking <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12137","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T02:17:22Z","timestamp":1377569842000},"source":"Crossref","is-referenced-by-count":15,"title":["The Importance of Histopathological Diagnosis in the Management of Lesions Presenting as Peri\u2010Implantitis"],"prefix":"10.1111","volume":"17","author":[{"given":"Ilana","family":"Kaplan","sequence":"first","affiliation":[{"name":"Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv"},{"name":"Department of Pathology Sackler School of Medicine Tel\u2010Aviv University  Ramat\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avraham","family":"Hirshberg","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Oral Medicine The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Shlomi","sequence":"additional","affiliation":[{"name":"Tel\u2010Aviv Sourasky Medical Center Tel\u2010Aviv and Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Platner","sequence":"additional","affiliation":[{"name":"Department of Periodontology Goldschleger School of Dental Medicine Tel\u2010Aviv University  Ramat\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avital","family":"Kozlovsky","sequence":"additional","affiliation":[{"name":"Department of Periodontology Goldschleger School of Dental Medicine Tel\u2010Aviv University  Ramat\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Ofec","sequence":"additional","affiliation":[{"name":"private dental practice and Biostatistics  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devorah","family":"Schwartz\u2010Arad","sequence":"additional","affiliation":[{"name":"Schwartz\u2010Arad Day Care Surgical Center  Ramat\u2010Hasharon Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01283.x"},{"key":"e_1_2_6_3_1","first-page":"365","volume-title":"Proceedings of the First European Workshop on periodontology","author":"Albrektsson T","year":"1994"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-10-00134"},{"issue":"8","key":"e_1_2_6_5_1","first-page":"282","article-title":"Non\u2010surgical treatment of peri\u2010implant mucositis and peri\u2010implantitis: a literature review","volume":"35","author":"Renvert S","year":"2008","journal-title":"J Clin Periodontol"},{"key":"e_1_2_6_6_1","first-page":"138","article-title":"Peri\u2010implantitis \u2013 a risk factor in implant failure","volume":"5","author":"Gupta HK","year":"2011","journal-title":"J Clin Diag Res"},{"issue":"3","key":"e_1_2_6_7_1","article-title":"Interventions for replacing missing teeth: treatment of perimplantitis","author":"Esposito M","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01672.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010013\u20100968\u20105"},{"key":"e_1_2_6_10_1","first-page":"563","article-title":"Metastases and primary tumors around dental implants: a literature review and case report of peri\u2010implant pulmonary metastasis","volume":"43","author":"Pfammatter C","year":"2012","journal-title":"Quintessence Int"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.06.184"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e31824cde85"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.9.1381"},{"key":"e_1_2_6_14_1","first-page":"295","article-title":"Peripheral giant cell granuloma associated with a dental implant","volume":"19","author":"Bischof M","year":"2004","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.08.003"},{"key":"e_1_2_6_16_1","first-page":"529","article-title":"Peripheral giant cell granuloma associated with a dental implant. 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