{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:59:45Z","timestamp":1790283585989,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T00:00:00Z","timestamp":1379376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this systematic review was to evaluate clinical and safety data for recombinant human bone morphogenetic protein\u20102 (rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102) in an absorbable collagen sponge (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>) carrier when used for alveolar ridge\/maxillary sinus augmentation in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Clinical studies\/case series published 1980 through <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>une 2012 using rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> were searched. Studies meeting the following criteria were considered eligible for inclusion: &gt;10 subjects at baseline and maxillary sinus or alveolar ridge augmentation not concomitant with implant placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven of 69 publications were eligible for review. rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> yielded clinically meaningful bone formation for maxillary sinus augmentation that would allow placement of regular dental implants without consistent differences between rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 concentrations. Nevertheless, the statistical analysis showed that sinus augmentation following autogenous bone graft was significantly greater (mean bone height: 1.6\u2009mm, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.5\u20132.7\u2009mm) than for rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> (rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 at 1.5\u2009mg\/m<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>). In extraction sockets, rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> maintained alveolar ridge height while enhancing alveolar ridge width. Safety reports did not represent concerns for the proposed indications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> appears a promising alternative to autogenous bone grafts for alveolar ridge\/maxillary sinus augmentation; dose and carrier optimization may expand its efficacy, use, and clinical application.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12156","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T13:55:40Z","timestamp":1381240540000},"source":"Crossref","is-referenced-by-count":81,"title":["Alveolar Ridge and Maxillary Sinus Augmentation Using rh<scp>BMP<\/scp>\u20102: A Systematic Review"],"prefix":"10.1111","volume":"17","author":[{"given":"Rubens Moreno","family":"de Freitas","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis and Surgery 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Dias","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology UNICAMP \u2013 Universidade Estadual de Campinas Institute of Biology  Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf ME","family":"Wikesj\u00f6","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Department of Periodontics and Oral Biology College of Dental Medicine Department of Orthopedic Surgery Medical College of Georgia Georgia Regents University  Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Susin","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Department of Periodontics and Oral Biology College of Dental Medicine Department of Orthopedic Surgery Medical College of Georgia Georgia Regents University  Augusta GA 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