{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:00:49Z","timestamp":1790694049083,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A recent study conducted in humans demonstrated for the first time that bone loss in the immediate period after implant insertion before loading did not significantly differ in organ transplant recipients with respect to normal subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study is to evaluate bone and periodontal response and peri\u2010implant microflora in a group of organ\u2010transplanted patients 1 year after prosthetic loading.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      The study population included 13 consecutive organ\u2010transplanted (11 hearts, two livers) patients and 13 normal (healthy) control subjects who received 29 and 28 submerged dental implants, respectively. Crestal bone level, peri\u2010implant probing depth (\n                      <jats:styled-content style=\"fixed-case\">PIPD<\/jats:styled-content>\n                      ), and bleeding on probing were evaluated at prosthetic loading and after 1 year. Samples for microbiological testing were taken from the subgingival microbiota of each implant 1 year after loading and analyzed with polymerase chain reaction. All samples were examined for the presence of five microorganisms:\n                      <jats:italic>Treponema denticola<\/jats:italic>\n                      ,\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      ,\n                      <jats:italic>Prevotella intermedia<\/jats:italic>\n                      ,\n                      <jats:italic>Tannarella forsythensis<\/jats:italic>\n                      , and\n                      <jats:italic>Actinobacillus actinomycetemcomitans.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A mean bone loss of 0.17\u2009\u00b1\u20090.10 and 0.20\u2009\u00b1\u20090.10\u2009mm at 1 year was observed in the group of transplant recipients and in controls, respectively (\n                      <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      .). Similar results were obtained considering\n                      <jats:styled-content style=\"fixed-case\">PIPD<\/jats:styled-content>\n                      changes at 1 year (respectively 0.06\u2009\u00b1\u20090.71\u2009mm in transplants vs 0.11\u2009\u00b1\u20090.74\u2009mm in controls). Detection frequencies of pathogens were not statistically different between normal and transplanted patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present pilot study seems to indicate that bone and periodontal response and microbiological status around submerged dental implants in immunocompromised organ\u2010transplanted patients do not differ 1 year after loading from those observed in control patients and that this particular population of patients may be successfully rehabilitated with dental implants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.12207","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T13:13:04Z","timestamp":1393247584000},"page":"972-982","source":"Crossref","is-referenced-by-count":29,"title":["Peri\u2010Implant Response and Microflora in Organ Transplant Patients 1 Year after Prosthetic Loading: A Prospective Controlled Study"],"prefix":"10.1111","volume":"17","author":[{"given":"Lucio","family":"Montebugnoli","sequence":"first","affiliation":[{"name":"Section of Oral Science Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Venturi","sequence":"additional","affiliation":[{"name":"Section of Oral Science Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Cervellati","sequence":"additional","affiliation":[{"name":"Section of Oral Science Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Servidio","sequence":"additional","affiliation":[{"name":"Section of Oral Science Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Vocale","sequence":"additional","affiliation":[{"name":"Unit of Microbiology Regional Reference Centre for Microbiological Emergencies St. Orsola Malpighi University Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Pagan","sequence":"additional","affiliation":[{"name":"Unit of Microbiology Regional Reference Centre for Microbiological Emergencies St. Orsola Malpighi University Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Landini","sequence":"additional","affiliation":[{"name":"Unit of Microbiology Regional Reference Centre for Microbiological Emergencies St. Orsola Malpighi University Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Magnani","sequence":"additional","affiliation":[{"name":"Cardiovascular Department University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Sambri","sequence":"additional","affiliation":[{"name":"Unit of Clinical Microbiology The Hub Laboratory of the Greater Romagna Area  Pievesestina Cesena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.06.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.03.044"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302006000400023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2007.07.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.6.909"},{"key":"e_1_2_7_7_1","first-page":"472","article-title":"Eleven dental implants placed in a liver transplantation patient: a case report and 5\u2010year clinical evaluation","volume":"124","author":"Gu L","year":"2011","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_7_8_1","first-page":"1494","article-title":"Bone response to submerged implants in organ transplant patients: a prospective controlled study","volume":"27","author":"Montebugnoli L","year":"2012","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.050955"},{"key":"e_1_2_7_10_1","first-page":"199","volume-title":"Tissue\u2010integrated prostheses. 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