{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:54:32Z","timestamp":1767992072237,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"BTI Biotechnology Institute"},{"name":"ARDEC, Ariminum Odontologica SRL"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this paper was to study the sequential healing of bone tissues at implants with different configuration and different modified surfaces.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twelve <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>eagle dogs were used. Extractions of all teeth from the second premolar to the first molar were performed in both sides of the mandible. After 3 months, full\u2010thickness flaps were elevated and two implants of different systems and with different surfaces were randomly installed in the premolar region in one side of the mandible. One surface was acid etched and further modified with calcium ions (<jats:styled-content style=\"fixed-case\">BTI unicCa<\/jats:styled-content>\u00ae), the other was sandblasted and acid etched plus a nanometer calcium phosphate deposition (3i <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>3\u00ae). The flaps were sutured to allow a fully submerged healing. The surgery on the other side of the mandible and the sacrifices were planned in such a way to obtain biopsies representing the healing after 1, 2, 4, and 8 weeks (<jats:italic>n<\/jats:italic>\u2009=\u20096 per period).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 1 and 2 weeks of healing, the mean values of new bone apposition on the implant surfaces were 5.9\u2009\u00b1\u20093.3% and 29.8\u2009\u00b1\u200916.0% at <jats:styled-content style=\"fixed-case\">BTI unicCa<\/jats:styled-content> and 4.6\u2009\u00b1\u20093.3% and 12.4\u2009\u00b1\u20095.6% at 3i <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>3, respectively. After 4 and 8 weeks, the percentage increased, being 49.4\u2009\u00b1\u20098.1% and 63.6\u2009\u00b1\u20097.3% at <jats:styled-content style=\"fixed-case\">BTI unicCa<\/jats:styled-content> and 40.3\u2009\u00b1\u200910.0% and 47.3\u2009\u00b1\u200920.2 at 3i <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>3, respectively. Differences statistically significant between the two surfaces were found only at the 2\u2010 and 4\u2010week observation periods. Concomitantly, the old bone was resorbed at both surfaces from about 15\u201317% after 1 week to about 4\u20136% after 8 weeks of healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Moderately rough surfaces modified with calcium ions or discrete calcium phosphate nanocrystalline deposition showed similar patterns of sequential healing. Higher new bone percentages were found at <jats:styled-content style=\"fixed-case\">BTI unicCa<\/jats:styled-content> compared with the 3i <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>3 implants, the difference being statistically significant at 2 and 4 weeks observation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12311","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T09:06:51Z","timestamp":1425287211000},"page":"369-378","source":"Crossref","is-referenced-by-count":22,"title":["Sequential Healing at Calcium\u2010 versus Calcium Phosphate\u2010Modified Titanium Implant Surfaces: An Experimental Study in Dogs"],"prefix":"10.1111","volume":"18","author":[{"given":"Riccardo","family":"Favero","sequence":"first","affiliation":[{"name":"University of Medicine School of Dentistry  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Botticelli","sequence":"additional","affiliation":[{"name":"ARDEC, Ariminum Odontologica  Rimini Italy"},{"name":"POI, Programa Odontol\u00f3gico Internacional  Cartagena de Indias Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio A.","family":"Antunes","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry S\u00e3o Paulo University  USP Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxanna","family":"Martinez Sanchez","sequence":"additional","affiliation":[{"name":"POI, Programa Odontol\u00f3gico Internacional  Cartagena de Indias Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marino","family":"Caroprese","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry University of Medical Science  La Habana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz A.","family":"Salata","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry S\u00e3o Paulo University  USP Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01775.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01082.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300704"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070157"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02107.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02172.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35240"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.07.020"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32126"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12389"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00972.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12097"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12475"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01533.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00693.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00568.x"}],"container-title":["Clinical Implant Dentistry and Related Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcid.12311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cid.12311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:46:42Z","timestamp":1696337202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cid.12311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,2]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/cid.12311"],"URL":"https:\/\/doi.org\/10.1111\/cid.12311","archive":["Portico"],"relation":{},"ISSN":["1523-0899","1708-8208"],"issn-type":[{"value":"1523-0899","type":"print"},{"value":"1708-8208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,2]]}}}