{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:20:40Z","timestamp":1780482040494,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["#22390368"],"award-info":[{"award-number":["#22390368"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bone mechanical function is regulated by bone quality and bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) that reflect bone strength. The preferential alignment of biological apatite (<jats:styled-content style=\"fixed-case\">BAp<\/jats:styled-content>) <jats:italic>c<\/jats:italic>\u2010axis\/collagen fibers and osteocytes is a determinant factor of bone quality. However, the effect of mechanical loading on bone quality around dental implants is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to clarify the effects of mechanical loading on osseointegration, bone volume <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>, and bone quality around dental implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty anodized <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>i\u20106<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>l\u20104<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> alloy implants (<jats:styled-content style=\"fixed-case\">KYOCERA C<\/jats:styled-content>o., <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>yoto, <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan) were placed in the proximal tibial metaphysis of 10 rabbits. Twelve weeks after surgery, mechanical loading was applied along the long axis of the implant (50\u2009<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>, 3\u2009<jats:styled-content style=\"fixed-case\">Hz<\/jats:styled-content>, 1,800\u2009cycles, 2 days\/week) for 8 weeks. Osseointegration, bone volume, <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>, and bone quality were evaluated using light microscopy, microcomputed tomography, polarized light microscopy, and microbeam <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray diffractometer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mechanical loading increased osseointegration, bone volume, and <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>. Bone quality around dental implant was altered with increased osteocyte numbers and the preferential alignment direction and degree of <jats:styled-content style=\"fixed-case\">BAp <jats:italic>c<\/jats:italic><\/jats:styled-content>\u2010axis\/collagen fibers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that mechanical loading effectively induces bone anabolic responses around dental implants. Altered bone quality may upregulate bone strength, contributing to long\u2010term implant stability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12318","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T18:46:47Z","timestamp":1427222807000},"source":"Crossref","is-referenced-by-count":21,"title":["Structural and Qualitative Bone Remodeling Around Repetitive Loaded Implants in Rabbits"],"prefix":"10.1111","volume":"17","author":[{"given":"Shinichiro","family":"Kuroshima","sequence":"first","affiliation":[{"name":"Department of Applied Prosthodontics Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munenori","family":"Yasutake","sequence":"additional","affiliation":[{"name":"Department of Applied Prosthodontics Graduate School of Biomedical Sciences Nagasaki University  Nagasaki 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