{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:35:54Z","timestamp":1780403754305,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CAPES (Brazil)"},{"name":"BoneTec Corporation (Canada)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is expected that 40% to 60% of initial alveolar bone volume will be lost up to 6 months after tooth extraction. <jats:styled-content style=\"fixed-case\">OsteoScaf<jats:sup>TM<\/jats:sup><\/jats:styled-content> (TRT, Toronto, ON, Canada) (poly (DL\u2010lactide\u2010co\u2010glycololide\/calcium phosphate [<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CaP<\/jats:styled-content>] scaffold) is a novel bone substitute material and represents a promising alternative for maintaining alveolar bone integrity in this clinical scenario.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Here it was hypothesized that <jats:styled-content style=\"fixed-case\">OsteoScaf<\/jats:styled-content> would reduce alveolar bone lost after tooth extraction in patient, acting as a clot\u2010retention device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 10 patients (32 sockets) were included in the study, of which 16 sockets were grafted with <jats:styled-content style=\"fixed-case\">OsteoScaf<\/jats:styled-content> and 16 were used as control (coagulum alone). <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>one beam computed tomography (<jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content>) was performed both immediately following extraction and also at 120 days postoperatively, at which time biopsy samples were also harvested for histological analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Quantitative analysis of <jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content> showed less bone resorption in the <jats:styled-content style=\"fixed-case\">OsteoScaf<\/jats:styled-content> groups, being 10.5% to 14.4% less bone lost in the center of the socket, 15.4% in the buccal region, and 12.6% in the palatal. Qualitative histological analysis showed new bone tissue in direct apposition to the scaffold \u2013 demonstrating its osteoconductive nature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">OsteoScaf<\/jats:styled-content> diminished the expected bone lost during the postextraction remodeling of the alveolar bone ridge at 120 days postextraction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12326","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T14:01:47Z","timestamp":1427292107000},"page":"559-570","source":"Crossref","is-referenced-by-count":19,"title":["Investigation of a Novel <scp>PLGA<\/scp>\/<scp>CaP<\/scp> Scaffold in the Healing of Tooth Extraction Sockets to Alveolar Bone Preservation in Humans"],"prefix":"10.1111","volume":"18","author":[{"given":"Ana Claudia","family":"Araujo\u2010Pires","sequence":"first","affiliation":[{"name":"School of Dentistry Stomatology and Oral Surgery Bauru University of S\u00e3o Paulo  Bauru S\u00e3o Paulo Brazil"},{"name":"Institute of Biomaterials and Biomedical Engineering University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Cristina","family":"Mendes","sequence":"additional","affiliation":[{"name":"Institute of Biomaterials and Biomedical Engineering University of Toronto  Toronto ON Canada"},{"name":"Dental Research Institute, Faculty of Dentistry University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osny","family":"Ferreira\u2010Junior","sequence":"additional","affiliation":[{"name":"School of Dentistry Stomatology and Oral Surgery Bauru University of S\u00e3o Paulo  Bauru S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo S\u00e9rgio Perri","family":"Carvalho","sequence":"additional","affiliation":[{"name":"School of Dentistry Stomatology and Oral Surgery Bauru 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