{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:05:26Z","timestamp":1763017526426},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Bone morphogenetic proteins (BMPs<\/jats:styled-content>) are members of the transforming growth factor\u2010\u03b2<\/jats:styled-content> (TGF\u03b2<\/jats:styled-content>) protein superfamily and are known to be involved in bone and cartilage formation. Within this family, BMP<\/jats:styled-content>\u20104 is one of the most studied members. It has been shown to induce osteogenic differentiation of osteoblasts and osteoprogenitor cells in vitro, but the intimate processes in which this protein promotes and regulates osseous repair still remains unclear.<\/jats:p><\/jats:sec>Purpose<\/jats:title>To assess whether the native cellular immunohistochemical expression of BMP<\/jats:styled-content>\u20104 correlates with the maturation of bone samples obtained at 6 months after maxillary sinus augmentation.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>Histopathological and histomorphometrical analyses were performed in all the samples, which were obtained from a total of 58 patients. Immunohistochemical expression of BMP<\/jats:styled-content>\u20104 was analyzed in 30 core biopsies obtained from maxillary sinuses grafted with a combination of anorganic bovine bone and autogenous cortical bone [1:1] (AB<\/jats:styled-content>\u2010group), and 18 biopsies from maxillary sinuses grafted solely with a cortico\u2010cancellous particulate allograft (M<\/jats:styled-content>\u2010group), all of them after a 6\u2010month healing period. Also, 10 biopsies of native pristine bone were obtained and used as control group (C<\/jats:styled-content>\u2010group).<\/jats:p><\/jats:sec>Results<\/jats:title>Mild to moderate immunohistochemical expression of native granular BMP<\/jats:styled-content>\u20104 was present in 56.8% (31.0% AB<\/jats:styled-content>\u2010group, 22.4% M<\/jats:styled-content>\u2010group, and 3.4% C<\/jats:styled-content>\u2010group) (p<\/jats:italic>\u2009=\u20090.000, chi\u2010square) of the specimens analyzed. BMP<\/jats:styled-content>\u20104 expression was primarily located in the cytoplasm of osteoblasts, osteoclasts, and epithelial cells of the schneiderian membrane. Whereas significant differences were observed in the proportion of mineralized tissue and cellularity between sinuses grafted with anorganic bovine bone, allograft, or nongrafted sinuses, there were no statistically significant differences in the cellular expression of BMP<\/jats:styled-content>\u20104 among groups.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our findings suggest that the native expression of BMP<\/jats:styled-content>\u20104 appears to be associated with normal bone homeostasis and reparation in grafted and nongrafted maxillary sites.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12354","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T12:16:46Z","timestamp":1431433006000},"page":"717-724","source":"Crossref","is-referenced-by-count":7,"title":["Significance of the Immunohistochemical Expression of Bone Morphogenetic Protein\u20104 in Bone Maturation after Maxillary Sinus Grafting in Humans"],"prefix":"10.1111","volume":"18","author":[{"given":"Laura","family":"Torrecillas\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Oral Surgery and Implant Dentistry Department School of Dentistry University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Galindo\u2010Moreno","sequence":"additional","affiliation":[{"name":"Oral Surgery and Implant Dentistry Department School of Dentistry University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"\u00c1vila\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Department of Periodontics College of Dentistry University of Iowa Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Ortega\u2010Oller","sequence":"additional","affiliation":[{"name":"Oral Surgery and Implant Dentistry Department School of Dentistry University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Monje","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Hern\u00e1ndez\u2010Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery Department San Cecilio University Hospital of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Biopathology and Regenerative Medicine Institute (IBIMER) School of Medicine University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"O'Valle","sequence":"additional","affiliation":[{"name":"Department of Pathology and Biopathology and Regenerative Medicine Institute (IBIMER) School of Medicine University of Granada Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513518561"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(02)00026-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200101000-00018"},{"key":"e_1_2_8_5_1","first-page":"1349","article-title":"Enhanced in vivo osteogenesis by nanocarrier\u2010fused bone morphogenetic protein\u20104","volume":"8","author":"Shiozaki Y","year":"2013","journal-title":"Int J 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