{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:59:03Z","timestamp":1786420743485,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of the present study was to evaluate if the presence of granulation tissue in asymptomatic apical periodontitis compromised immediate implant placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients requiring extraction of one tooth (maxillary and mandibular incisive, canine or premolar) with asymptomatic apical periodontitis, were recruited for this prospective study. They were randomly scheduled into two groups: in first group (A) including 30 teeth, reactive soft tissue was debrided before implant placement, and in second group (B) including 30 teeth, reactive soft tissue was left in the apical lesion. Implants were positioned immediately after tooth extraction, and were loaded after 3 months in both groups. Cone beam computed tomography was performed before tooth extraction and at 1\u2010year follow\u2010up to evaluate the radiolucency around the root apex and the implant, bucco\u2010lingual bone levels were also checked.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty patients were included in this study. Sixty implants were placed immediately after tooth extraction and, at 1\u2010year follow\u2010up, a survival rate of 100% was reported. After one year both groups showed absence of radiolucent zone at the apical region of implants. All fresh sockets presented a buccal\u2010palatal bone reduction in both groups after one year, even if not statistically significant differences were found between baseline bone levels and within groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within the limitations of the present study, the immediate placement of implants into the extraction sockets with asymptomatic apical periodontitis, in presence of primary stability, did not lead to an increased rate of complications and rendered an equally favorable type of tissue integration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12422","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T09:19:39Z","timestamp":1462007979000},"page":"20-27","source":"Crossref","is-referenced-by-count":29,"title":["Immediate Implant Placement in Sockets with Asymptomatic Apical Periodontitis"],"prefix":"10.1111","volume":"19","author":[{"given":"Roberto","family":"Crespi","sequence":"first","affiliation":[{"name":"Adjunct Professor, Department of Dentistry Vita Salute University, San Raffaele Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Cappar\u00e9","sequence":"additional","affiliation":[{"name":"Researcher, Department of Dentistry Vita Salute University, San Raffaele Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Crespi","sequence":"additional","affiliation":[{"name":"Insubria University Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lo Giudice","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Dental Sperimental Sciences University of Messina, Messina, Italy, \u201cG.Martino\u201d Hospital, V. 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Valeria Gazzi Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Gastaldi","sequence":"additional","affiliation":[{"name":"Associate Professor, Dental School Vita Salute University, Milan, Italy and San Rocco Hospital Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Gherlone","sequence":"additional","affiliation":[{"name":"Full Professor and Chairmen, Department of Dentistry Vita Salute University, San Raffaele Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"27","article-title":"Morphologic changes of the mandible after extraction and wearing of dentures","volume":"18","author":"Carlsson GE","year":"1967","journal-title":"Odontol 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