{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:38:21Z","timestamp":1792298301289,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:00:00Z","timestamp":1465430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To clinically and radiographically evaluate bone regeneration of severe horizontal bone defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study was designed as a single cohort, prospective clinical trial. Partially or fully edentulous patients, having less then 4 mm of residual horizontal bone width were selected and consecutively treated with resorbable collagen membranes and a 1:1 mixture of particulated anorganic bovine bone and autogenous bone, 7 months before implant placement. Tapered body implants were inserted and loaded 3 to 6 months later with a screw retained crown or bridge. Outcomes were: implant survival rate, any biological and prosthetic complications, horizontal alveolar bone dimensional changes measured on cone beam computed tomography (CBCT) taken at baseline and at implant insertion, peri\u2010implant marginal bone level changes measured on periapical radiographs, plaque index (PI), and bleeding on probing index (BoP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen consecutive patients (11 females, 7 males) with a mean age of 56.8 years (range 24\u201378) and 22 treated sites received 55 regular platform implants. No patient dropped\u2010out and no implants failed during the entire follow\u2010up, resulting in a cumulative implant survival rate of 100%. No prosthetic or biological complications were recorded. Supraimposition of pre\u2010 and 7\u2010month post\u2010operative CBCT scans revealed an average horizontal bone gain of 5.03\u2009\u00b1\u20092.15 mm (95% CI: 4.13\u20135.92 mm). One year after final prosthesis delivery, mean marginal bone loss was 1.03\u2009\u00b1\u20090.21 mm (95% CI 0.83\u20131.17 mm). PI was 11.1% and BoP was 5.6%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitation of the present study, high implant survival rate and high average bone augmentation seem to validate the use of collagen resorbable membranes with a 1:1 mixture of particulated anorganic bovine bone and autogenous bone, for the reconstruction of severe horizontal ridge defects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12429","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T00:29:54Z","timestamp":1465518594000},"page":"38-45","source":"Crossref","is-referenced-by-count":72,"title":["Horizontal Ridge Augmentation using GBR with a Native Collagen Membrane and 1:1 Ratio of Particulated Xenograft and Autologous Bone: A 1\u2010Year Prospective Clinical Study"],"prefix":"10.1111","volume":"19","author":[{"given":"Silvio Mario","family":"Meloni","sequence":"first","affiliation":[{"name":"Assistant Professor, University of Sassari  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha A","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"associated professor, Loma Linda University  CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Urban","sequence":"additional","affiliation":[{"name":"Assistant professor, Loma Linda University  CA USA; Urban Regeneration Institute, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Canullo","sequence":"additional","affiliation":[{"name":"Independent Researcher in Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Pisano","sequence":"additional","affiliation":[{"name":"private practice in Sassari  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Tallarico","sequence":"additional","affiliation":[{"name":"Lecturer, University of Sassari  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02546.x"},{"key":"e_1_2_6_3_1","first-page":"49","article-title":"Which hard tissue augmentation techniques are the most successful in furnishing bony support for implant placement","volume":"22","author":"Aghaloo TL","year":"2007","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_4_1","first-page":"696","article-title":"The efficacy of various bone augmentation procedures for dental implants: a Cochrane systematic review of randomized controlled clinical trials","volume":"21","author":"Esposito M","year":"2006","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012001035.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(88)80047-X"},{"key":"e_1_2_6_7_1","first-page":"109","article-title":"Long\u2010term stability of osseointegrated implants in augmented bone: a 5\u2010year prospective study in partially edentulous patients","volume":"22","author":"Buser D","year":"2002","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02262.x"},{"key":"e_1_2_6_9_1","first-page":"502","article-title":"Vertical ridge augmentation using guided bone regeneration (GBR) in three clinical scenarios prior to implant placement: a retrospective study of 35 patients 12 to 72 months after loading","volume":"24","author":"Urban IA","year":"2009","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-09-00004.1"},{"key":"e_1_2_6_11_1","first-page":"CD003607","article-title":"Interventions for replacing missing teeth: bone augmentation techniques for dental implant treatment","author":"Esposito M","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1999.100404.x"},{"key":"e_1_2_6_13_1","first-page":"13","article-title":"Healing pattern of bone regeneration in membrane\u2010protected defects: a histologic study in the canine mandible","volume":"9","author":"Schenk RK","year":"1994","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(96)90113-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.1407"},{"key":"e_1_2_6_16_1","first-page":"233","article-title":"Bone regeneration around titanium dental implants in dehisced defect sites: a clinical study","volume":"7","author":"Jovanovic SA","year":"1992","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.563664"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e31827f3576"},{"key":"e_1_2_6_19_1","first-page":"39","article-title":"Postextraction socket preservation using epithelial connective tissue graft vs porcine collagen matrix. 1\u2010year results of a randomised controlled trial","volume":"8","author":"Meloni SM","year":"2015","journal-title":"Eur J Oral Implantol"}],"container-title":["Clinical Implant Dentistry and Related Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcid.12429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcid.12429","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cid.12429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:07:01Z","timestamp":1696356421000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cid.12429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,9]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/cid.12429"],"URL":"https:\/\/doi.org\/10.1111\/cid.12429","archive":["Portico"],"relation":{},"ISSN":["1523-0899","1708-8208"],"issn-type":[{"value":"1523-0899","type":"print"},{"value":"1708-8208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,9]]}}}