{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:41:09Z","timestamp":1789594869800,"version":"build-2803163510"},"reference-count":94,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Brazilian funding agency Coordination for the Improvement of Higher Education Personnel"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe alveolar atrophy often presents a challenge for the implant surgery. The significant lack of bone in the alveolar ridges may compromise the final restorations both from the aesthetic and functional standpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the behavior of bone block allografts for the maxillary augmentation and to investigate its incorporation, remodeling, and implant survival rates in two different healing time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Sixty\u2010six consecutive patients (52 female\/14 male, mean age: 57.95\u2009\u00b1\u20099.06 years old), presenting 113 atrophic alveolar ridges underwent maxillary augmentation with fresh\u2010frozen allogeneic bone blocks from tibia. Patients were randomly assigned in two groups: Group 1\u2014patients who would wait 4 months for implant placement after grafting, and Group 2\u2014patients who would wait 6 months. Events of infection, suture dehiscence or mucosal perforation were recorded. Cone\u2010beam computed tomography scans were compared volumetrically between the time of the grafting surgery and reentry procedure after incorporation. Biopsies were collected and subjected to histological, histomorphometric and immunehistochemical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 305 implants were placed in the reconstructed sites. The mean resorption rate in Group 1 (13.98%\u2009\u00b1\u20095.59) was significantly lower than Group 2 (31.52%\u2009\u00b1\u20096.31). The amount of calcified tissue, newly formed bone and remaining graft particles demonstrated no difference between groups. The samples showed evident immunolabeling for the podoplanin protein in both groups. The implants cumulative survival rate was 94.76%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of the present study indicate that there is a significant difference regarding the resorption of the grafts when waiting 4 or 6 months before placing the implants, even though no difference was found in the histological, histomorphometric, and immunohistochemical features. Both 4\u2010month and 6\u2010months healing times are suitable for the implant placement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12441","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T08:10:01Z","timestamp":1473408601000},"page":"180-194","source":"Crossref","is-referenced-by-count":22,"title":["Incorporation and Remodeling of Bone Block Allografts in the Maxillary Reconstruction: A Randomized Clinical Trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4959-528X","authenticated-orcid":false,"given":"Daniel","family":"Deluiz","sequence":"first","affiliation":[{"name":"Postdoctoral researcher, Department of Periodontology State University of Rio de Janeiro RJ, Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Santos Oliveira","sequence":"additional","affiliation":[{"name":"Professor, Department of Implantology Pontifical Catholic University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio","family":"Ram\u00f4a Pires","sequence":"additional","affiliation":[{"name":"Professor, Department of Stomatology, Est\u00e1cio de S\u00e1 University Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresita","family":"Reiner","sequence":"additional","affiliation":[{"name":"Investigator, Geriatric Research, Education and Clinical Center \u2010 Bruce W. 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