{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:53:52Z","timestamp":1769831632417,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T00:00:00Z","timestamp":1479254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371190"],"award-info":[{"award-number":["81371190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the influence of maturation timing upon histological, histomorphometric and clinical outcomes when deproteinized bovine bone mineral (DBBM) was used as a sole biomaterial for staged maxillary sinus floor augmentation (MSFA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Patients with a posterior edentulous maxillary situation and a vertical bone height\u2009\u2264\u20094 mm were included in this study. A staged MSFA was carried out. After MSFA with DBBM as a sole grafting material, biopsy cores were harvested with simultaneous implant placement followed by a healing period of 5, 8, and 11 months, respectively. Micro\u2010CT, histologic and histomorphometric analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010one patients were enrolled and 38 bone core biopsies were harvested. Significantly greater BV\/TV was observed between 5\u2010 and 8\u2010month healing from micro\u2010CT analysis. Histomorphometric analyses showed the ratio of mineralized newly formed bone increased slightly from 5 to 11 months; however, no statistically significant difference was reached (<jats:italic>p<\/jats:italic>\u2009=\u2009.409). Residual bone substitute decreased from 37.3\u2009\u00b1\u20095.04% to 20.6\u2009\u00b1\u20097.45%, achieving a statistical significant difference from of 5 up to 11 months (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Moreover, no implant failure, biological or technical complication occurred after 12\u2010month follow\u2010up of functional loading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DBBM utilized as sole grafting material in staged MSFA demonstrated to be clinically effective regardless of the healing period. Histomorphometrical and micro\u2010CT assessments revealed that at later stages of healing (8 and 11 months) there is a higher proportion of newly\u2010bone formation compared to earlier stages (5 months). Moreover, the longer the maturation period, the substantially lesser remaining biomaterial could be expected. Even though, these facts did not seem to negatively impact on the implant prognosis 1\u2010year after loading.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12463","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T19:42:53Z","timestamp":1479325373000},"page":"341-350","source":"Crossref","is-referenced-by-count":13,"title":["Influence of Healing Period Upon Bone Turn Over on Maxillary Sinus Floor Augmentation Grafted Solely with Deproteinized Bovine Bone Mineral: A Prospective Human Histological and Clinical Trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Feng","family":"Wang","sequence":"first","affiliation":[{"name":"Assistant professor, Department of Oral Implantology, Ninth People's Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology Shanghai China 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