{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:13:59Z","timestamp":1788912839811,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few studies have been conducted to assess new bone formation using Biogran, a bioactive glass, in maxillary sinus bone augmentation through a prospective and randomized evaluation. Moreover, there are no studies that evaluate cellular behavior by immunohistochemical assessment for osteoblastic and vascular activity during bone repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of this study is to compare new bone formation and cellular behavior with Biogran alone, a 1:1 combination of Biogran and autogenous bone graft, and autogenous bone graft alone in human maxillary sinuses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Ten maxillary sinuses were grafted with Biogran (Group 1), 10 grafted with Biogran added to autogenous bone graft in a 1:1 ratio (Group 2), and 10 grafted with autogenous bone graft alone (Group 3). After 6 months of bone healing, samples were obtained concurrent to the dental implants' placement to be evaluated by histomorphometric and immunohistochemical assessment for RUNX2 and vascular endothelial growth factor (VEGF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The amount of new bone formation in Group 1 was 42.0\u2009\u00b1\u20097.3% in the pristine bone region, 40.7\u2009\u00b1\u200914.0% in the intermediate region, and 45.6\u2009\u00b1\u200913.5% in apical region. In Group 2, for pristine bone, intermediate, and apical regions, new bone formation was 36.6\u2009\u00b1\u200912.9%, 33.2\u2009\u00b1\u200913.3%, and 45.8\u2009\u00b1\u200913.9%, respectively. Group 3 showed new bone formation of 37.3\u2009\u00b1\u200911.6%, 35.3\u2009\u00b1\u200914.7%, and 39.9\u2009\u00b1\u200915.8% in pristine bone, intermediate, and apical regions, respectively. The immunolabeling for RUNX2 showed low cellular activity in osteoblasts for all groups, and the VEGF assessment demonstrated moderate cellular activity in Groups 1 and 2; however, Group 3 presented with low activity in the pristine bone region, followed by moderate activity in the intermediate and apical region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that Biogran and its combination with autogenous bone graft 1:1 are good bone substitutes due to their similarity to autogenous bone graft.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.12507","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T02:16:57Z","timestamp":1497320217000},"page":"867-875","source":"Crossref","is-referenced-by-count":40,"title":["Histomorphometric and immunohistochemical assessment of RUNX2 and VEGF of Biogran\u2122 and autogenous bone graft in human maxillary sinus bone augmentation: A prospective and randomized study"],"prefix":"10.1111","volume":"19","author":[{"given":"Rodrigo dos Santos","family":"Pereira","sequence":"first","affiliation":[{"name":"Universidade Estadual Paulista \u2013 UNESP, Surgery and Integrated Clinic Department S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Dreyer","family":"Menezes","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \u2013 UNESP, Surgery and Integrated Clinic Department S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Paulo","family":"Bonardi","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \u2013 UNESP, Surgery and Integrated Clinic Department S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo 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