{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:29:01Z","timestamp":1791037741739,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research Project Fund of Ataturk University","award":["2011\/33"],"award-info":[{"award-number":["2011\/33"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The potential effects of adding pure platelet\u2010rich plasma (P\u2010PRP) or platelet\u2010rich fibrin (PRF) to beta\u2010tricalcium phosphate (\u03b2\u2010TCP) graft substitute on bone formation and regeneration after maxillary sinus\u2010floor elevation remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the histologic and histomorphometric outcomes of maxillary sinus\u2010floor augmentation among \u03b2\u2010TCP alone, P\u2010PRP\u2010mixed \u03b2\u2010TCP, and PRF\u2010mixed \u03b2\u2010TCP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>In this randomized clinical trial, elevated sinus cavities were grafted with \u03b2\u2010TCP (the control group), P\u2010PRP\u2010mixed \u03b2\u2010TCP (the P\u2010PRP group), and PRF\u2010mixed \u03b2\u2010TCP (PRF group). The sample was composed of 26 patients: 9 subjects in control and P\u2010PRP groups, and 8 subjects in PRF group. After a 6\u2010month, healing period, bone graft biopsies were harvested prior to implant placement, and the specimens were analyzed. The main outcome variables included findings of histologic and histomorphometric analyses of the bone graft biopsies. The data were analyzed by ANOVA and Tukey HSD tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean percentages of new bone formations were 33.40\u2009\u00b1\u200910.43%, 34.83\u2009\u00b1\u200910.12%, and 32.03\u2009\u00b1\u20096.34% in control, P\u2010PRP, and PRF groups, respectively, with no significant differences (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u2009.05). Mean percentages of residual graft particle area were 30.39\u2009\u00b1\u200910.29%, 28.98\u2009\u00b1\u20097.94%, and 32.66\u2009\u00b1\u20097.46% in control, P\u2010PRP, and PRF groups, respectively, with no significant differences (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u2009.05). The mean percentages of soft\u2010tissue area were 36.21\u2009\u00b1\u200910.59%, 36.19\u2009\u00b1\u200913.94%, and 35.31\u2009\u00b1\u200910.81% in control, P\u2010PRP, and PRF groups, respectively, with no significant differences (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u2009.05). Mean densities of osteoblasts, osteoclasts, osteocytes, and capillary vessels showed insignificant difference between groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u2009.05), but osteoprogenitor cells were lower and inflammatory cells were higher in the PRF group than those in other groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01). Biopsies of P\u2010PRP, PRF, and control groups showed similar composition and distribution of histologic structures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggested that adding P\u2010PRP or PRF to \u03b2\u2010TCP graft substitute was not beneficial on new bone formation and regeneration, and P\u2010PRP plus \u03b2\u2010TCP or PRF plus \u03b2\u2010TCP is not superior to \u03b2\u2010TCP alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.12522","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T03:22:46Z","timestamp":1501039366000},"page":"959-967","source":"Crossref","is-referenced-by-count":70,"title":["Histologic and histomorphometric assessment of sinus\u2010floor augmentation with beta\u2010tricalcium phosphate alone or in combination with pure\u2010platelet\u2010rich plasma or platelet\u2010rich fibrin: A randomized clinical trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Song\u00fcl","family":"C\u00f6mert K\u0131l\u0131\u00e7","sequence":"first","affiliation":[{"name":"Ministry of Health, Department of Oral and Maxillofacial Surgery Center for Oral and Dental Health Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"G\u00fcng\u00f6rm\u00fc\u015f","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Gaziantep University Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u00e7il Nazife","family":"Parlak","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Faculty of Medicine, Ataturk University Erzurum 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