{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:33:07Z","timestamp":1789237987797,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T00:00:00Z","timestamp":1508112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertension is considered a risk factor in implant dentistry but the underlying reasons remain unclear. It may be that hypertension has a negative impact on the local bone quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Here we evaluated the structural and histological parameters of bone collected from hypertensive patients treated by antagonists of the renin\u2010angiotensin system, and of bone collected from normotensive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A total of 30 patients were referred for rehabilitation with dental implants to be placed in the posterior mandible. The first group were hypertensive patients treated with RAS antagonists. The second group were normotensive patients not taking medication. Bone biopsies collected during implant installation were subjected to analysis. Micro CT revealed the structural parameters. Histological analyses together with immunohistochemical staining of osteogenic markers were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The structural parameters of bone volume, trabecular thickness, trabecular number, separation of the trabecular, and total porosity were similar between the 2 groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). The histological appearance of bone derived from hypertensive patients was normal. The staining pattern of Runx\u20102, osteopontin, and osteocalcin were comparable in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These observations suggest that hypertensive patients treated with renin\u2010angiotensin system antagonists have regular alveolar bone with respect to bone structure and histological parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12548","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T06:12:45Z","timestamp":1508134365000},"page":"1106-1113","source":"Crossref","is-referenced-by-count":12,"title":["Morphometric and histologic characterization of alveolar bone from hypertensive patients"],"prefix":"10.1111","volume":"19","author":[{"given":"Andr\u00e9 Lu\u00eds da Silva","family":"Fabris","sequence":"first","affiliation":[{"name":"Department of Surgery and Integrated Clinic Ara\u00e7atuba Dental School, UNESP\u2014Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Mulinari\u2010Santos","sequence":"additional","affiliation":[{"name":"Department of Surgery and Integrated Clinic Ara\u00e7atuba Dental School, UNESP\u2014Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline Suemi","family":"Hassumi","sequence":"additional","affiliation":[{"name":"Division of Anatomy, Department of Basic Science Ara\u00e7atuba Dental School, UNESP\u2014Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Rodrigues","family":"Freire","sequence":"additional","affiliation":[{"name":"Department of Morphology Piracicaba Dental School, State University of Campinas Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Perez","family":"Faverani","sequence":"additional","affiliation":[{"name":"Department of Surgery and Integrated Clinic Ara\u00e7atuba Dental School, UNESP\u2014Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, School of Dentistry Medical University of Vienna Vienna Austria"},{"name":"Department of Periodontology, School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Anatomy, Department of Basic Science Ara\u00e7atuba Dental School, UNESP\u2014Universidade Estadual Paulista \u201cJ\u00falio de Mesquita 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