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The combined biomarkers were identified using principal component analysis, and the pathway enrichment analyses were performed using the DAVID online tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred differently expressed genes between groups were detected according to the significances. From functional annotation, Y\u2010box binding protein 1 and heterogeneous nuclear ribonucleoprotein C were found to be included in the most significant 10 pathways. Ten combined gene sets were identified that were effective in classifying multiple myeloma (MM) with ONJ and MM without ONJ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Identifying combined gene expression profiles is expected to contribute to more personalized management of BRONJ and to improve existing therapies, and it will be helpful in finding new therapies by identifying more predictive biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12569","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T07:57:10Z","timestamp":1513756630000},"page":"191-198","source":"Crossref","is-referenced-by-count":4,"title":["Identifying a combined biomarker for bisphosphonate\u2010related osteonecrosis of the jaw"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-1067","authenticated-orcid":false,"given":"Ki\u2010Yeol","family":"Kim","sequence":"first","affiliation":[{"name":"Dental Education Research Center, BK21 PLUS Project Yonsei University College of Dentistry Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianglan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Yanbian University Medical College Yanji City Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u2010Ho","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery College of Dentistry, Yonsei University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"volume-title":"Drug Treatment","year":"2012","author":"National Osteoporosis Society","key":"e_1_2_7_2_1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2005.tb06761.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4065\/83.9.1032"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.08.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.16.S3.1"},{"key":"e_1_2_7_7_1","unstructured":"GauthierK BaiA PerrasC et al.Proceedings of the Denosumab Raloxifene and Zoledronic Acid for the Treatment of Postmenopausal Osteoporosis: Clinical Effectiveness and Harms. 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