{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:05:41Z","timestamp":1791270341375,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T00:00:00Z","timestamp":1535068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dental rehabilitation with conventional prostheses after microvascular jaw reconstruction is often unsuccessful because of the altered oral anatomy and the lack of adequate dentition for fixation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This retrospective study evaluated the long\u2010term outcomes of patients who underwent jaws reconstruction with a fibula free flap and subsequent rehabilitation with implant\u2010supported prostheses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In total, 21 patients were enrolled; 108 osseointegrated dental implants, positioned on 21 fibular free flaps were assessed. Follow\u2010up examinations were performed according to a standardized protocol, including clinical and radiological evaluations. The mean follow\u2010up after implant insertion was 90.2 (range, 20\u2010204) months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall implant survival rate was 97.2% at the 12\u2010month follow\u2010up, 86.5% at 60\u2009months, and 79.3% at 120\u2009months. The rate of overall implant success was 95.4% at the 12\u2010month follow\u2010up, 73.5% at 60\u2009months, and 64.7% at 120\u2009months. Implant failure was more common in patients that had implants placed after they underwent radiation therapy.<\/jats:p><jats:p>Peri\u2010implantitis and mucositis were identified in 14.8% and 20.3% of surviving implants, respectively, at the 5\u2010 and 10\u2010year follow\u2010up. The risk of developing peri\u2010implantitis was estimated to be higher (odds ratio\u2009=\u20091.5) for patients without connective tissue or skin grafts versus patients with one of them (18.2% vs 9.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term implant\u2010related outcomes show that the survival rate of implants placed into the fibula is acceptable. Radiotherapy negatively impacts survival and success, in particular in the short and medium\u2010term follow\u2010up. Moreover, a relevant peri\u2010implant bone resorption does occur over time and ultimately influences implants success, and it is mainly related to peri\u2010implant gingival mucositis. In this regard skin or connective tissue grafts seem to offer an aid to manage this problem.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12658","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T10:55:51Z","timestamp":1535108151000},"page":"852-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Long\u2010term results of osseointegrated implant\u2010based dental rehabilitation in oncology patients reconstructed with a fibula free flap"],"prefix":"10.1111","volume":"20","author":[{"given":"Gerardo","family":"Pellegrino","sequence":"first","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5815-7591","authenticated-orcid":false,"given":"Achille","family":"Tarsitano","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, Maxillofaccial Surgery University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Ferri","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Corinaldesi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Unit Policlinico S. 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