{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:07:12Z","timestamp":1774494432542,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011665","name":"Deanship of Scientific Research, King Saud University","doi-asserted-by":"publisher","award":["RG\u20101438\u2010075"],"award-info":[{"award-number":["RG\u20101438\u2010075"]}],"id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity seem to regulate peri\u2010implant health. It is proposed that peri\u2010implant crevicular fluid (PICF) levels of interleukin (IL)\u20101\u03b2 and IL\u20106 are higher in obese as compared to nonobese individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of the present clinico\u2010laboratory study is to estimate and compare the clinical and radiographic indices and PICF levels of IL\u20101\u03b2 and IL\u20106 among obese and nonobese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fifty patients were divided into two groups (25 obese with \u226527.5 kg\/m<jats:sup>2<\/jats:sup> and 25 nonobese with &lt;27.5 kg\/m<jats:sup>2<\/jats:sup> individuals). Clinical indices for both periodontal and peri\u2010implant evaluating plaque index (PI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), and crestal bone loss (CBL) were recorded around teeth and implants. PICF was collected and assessed for the levels of IL\u20101\u03b2 and IL\u20106 using enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant difference was observed in PI and BOP around natural teeth and implants in obese patients, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). CBL was found to be significantly higher among obese as compared to nonobese patients (<jats:italic>P<\/jats:italic>\u2009=\u2009.022). Peri\u2010implant and periodontal PD was higher in obese as compared to nonobese but did not reach statistical significance. Levels of IL\u20101\u03b2 and IL\u20106 were statistically significantly higher among obese patients as compared to nonobese (<jats:italic>P<\/jats:italic>\u2009=\u2009.001). Pearson correlation analysis showed IL\u20101\u03b2 was positively correlated with CBL (<jats:italic>P<\/jats:italic>\u2009=\u2009.0079), whereas IL\u20106 showed positive correlation with both BOP (<jats:italic>P<\/jats:italic>\u2009=\u2009.0019) and CBL (<jats:italic>P<\/jats:italic>\u2009=\u2009.015) among obese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical peri\u2010implant parameters were worse and proinflammatory biomarkers were significantly higher in obese patients compared with nonobese subjects. The findings of the present study suggests that increased proinflammatory biomarkers in PICF of obese patients may modulate peri\u2010implant inflammation around dental implants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12700","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T09:14:05Z","timestamp":1544692445000},"page":"80-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinical indices and local levels of inflammatory biomarkers in per\u2010implant health of obese and nonobese individuals"],"prefix":"10.1111","volume":"21","author":[{"given":"Mohammed N.","family":"Alasqah","sequence":"first","affiliation":[{"name":"Department of Preventive Dental Sciences College of Dentistry, Prince Sattam Bin Abdulaziz University  Alkharj Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouf","family":"Al\u2010Shibani","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dentistry King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khulud Abdulrahman","family":"Al\u2010Aali","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics College of Dentistry, Princess Nourah Bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama A.","family":"Qutub","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Prosthodontics, Faculty of Dentistry King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7266-5886","authenticated-orcid":false,"given":"Tariq","family":"Abduljabbar","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dental Science, College of Dentistry King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9618-8818","authenticated-orcid":false,"given":"Zohaib","family":"Akram","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Ziauddin University  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,13]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO. 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