{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:28:03Z","timestamp":1791037683283,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the effectiveness of adding leukocyte and platelet\u2010rich fibrin (L\u2010PRF) to deproteinized bovine bone mineral (DBBM) for early implant placement after maxillary sinus augmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twelve patients requiring two\u2010stage bilateral maxillary sinus augmentation were enrolled to the study. The elevated sinus cavities were randomly grafted with DBBM + L\u2010PRF (test) or DBBM alone (control) in a split\u2010mouth design. Implants were placed in the augmented sites after 4 months in the test group and 8 months in the control group. Bone biopsies were collected during implant placement for histomorphometric evaluation. Resonance frequency analysis was performed immediately after implant placement and at implant loading in both groups. Cone\u2010beam computed tomography was obtained preoperatively and postoperatively for evaluation of graft volume changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both procedures were effective for maxillary sinus augmentation. Cone\u2010beam computed tomography analysis did not reveal differences in graft volume between test and control group at any of the evaluated time points (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). Histological evaluation demonstrated increased percentage of newly formed bone for the test group (44.58%\u2009\u00b1\u200913.9%) compared to the control group (30.02%\u2009\u00b1\u20098.42%; <jats:italic>P<\/jats:italic>\u2009=\u2009.0087). The amount of residual graft in the control group was significantly higher (13.75%\u2009\u00b1\u20099.99%) than in the test group (3.59\u2009\u00b1\u20094.22; <jats:italic>P<\/jats:italic>\u2009=\u2009.0111). Implant stability quotient (ISQ) immediately after implant placement was significantly higher in the control group (75.13\u2009\u00b1\u20095.69) compared to the test group (60.9\u2009\u00b1\u20099.35; <jats:italic>P<\/jats:italic>\u2009=\u2009.0003). The ISQ values at loading did not differ between the groups (<jats:italic>P<\/jats:italic>\u2009=\u2009.8587). Implant survival rate was 100% for both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of L\u2010PRF to the DBBM into the maxillary sinus allowed early implant placement (4 months) with increased new bone formation than DBBM alone after 8 months of healing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12713","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T03:40:53Z","timestamp":1548733253000},"page":"253-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Evaluation of L\u2010PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial"],"prefix":"10.1111","volume":"21","author":[{"given":"Elton Carlos","family":"Pichotano","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery S\u00e3o Paulo State University (Unesp), School of Dentistry  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Scaf","family":"de Molon","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery S\u00e3o Paulo State University (Unesp), School of Dentistry  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Violante","family":"de Souza","sequence":"additional","affiliation":[{"name":"School of Medicine of Ribeirao Preto Sao Paulo University \u2013 USP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert S.","family":"Austin","sequence":"additional","affiliation":[{"name":"Tissue Engineering and Biophotonics King's College London Dental Institute, Guy's Hospital  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elcio","family":"Marcantonio","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery S\u00e3o Paulo State University (Unesp), School of Dentistry  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5442-7868","authenticated-orcid":false,"given":"Daniela Leal","family":"Zandim\u2010Barcelos","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery S\u00e3o Paulo State University (Unesp), School of Dentistry  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-14-00167"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.02.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2008.12.011"},{"key":"e_1_2_8_5_1","first-page":"237","article-title":"Bone augmentation procedures in implant dentistry","volume":"24","author":"Chiapasco M","year":"2009","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_6_1","first-page":"613","article-title":"Grafting of the maxillary sinus floor with autogenous marrow and bone","volume":"38","author":"Boyne PJ","year":"1980","journal-title":"J Oral Surg"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(22)02107-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.05.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01661.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12352"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12649"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.5832"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201300290"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2016.09.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2007.00050.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00176.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.06.053"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.01099.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-13-00129"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.012"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/850340"},{"key":"e_1_2_8_22_1","first-page":"ZC18","article-title":"Effect of platelet rich fibrin (PRF) on peri\u2010implant soft tissue and crestal bone in one\u2010stage implant placement: a randomized controlled trial","volume":"9","author":"Boora P","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12658"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32839"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-12-00104"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-12-00106"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-12-CL.3802"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01183.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13044"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-16-00104"},{"key":"e_1_2_8_31_1","article-title":"Enhancement of immediate implant stability and recovery using platelet\u2010rich fibrin","author":"\u00d6nc\u00fc E","year":"2017","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.07.025"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2613"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.008"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12528"},{"key":"e_1_2_8_36_1","first-page":"e601","article-title":"Positive effect of platelet rich fibrin on osseointegration","volume":"21","author":"\u00d6nc\u00fc E","year":"2016","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90029-4"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-012-9349-6"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0327"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-18"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2011.04.020"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22894"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02467.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-17-00220"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-15-00001"},{"key":"e_1_2_8_47_1","first-page":"218","article-title":"Bone augmentation procedures in localized defects in the alveolar ridge: clinical results with different bone grafts and bone\u2010substitute materials","volume":"24","author":"Jensen SS","year":"2009","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00251.x"},{"key":"e_1_2_8_49_1","first-page":"1075","article-title":"Trial with Platelet\u2010Rich Fibrin and Bio\u2010Oss used as grafting materials in the treatment of the severe maxillar bone atrophy: clinical and radiological evaluations","volume":"14","author":"Inchingolo F","year":"2010","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.01.021"},{"key":"e_1_2_8_51_1","first-page":"1958","article-title":"Influence of PRF in the healing of bone and gingival tissues. Clinical and histological evaluations","volume":"17","author":"Marrelli M","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090252"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.3897"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01487.x"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.3948"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12101"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002393"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.3472"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.120501.x"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2013.05.029"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v008a01"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12522"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.4414"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-2187"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00267.x"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12193"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.3903"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2002.tb00162.x"}],"container-title":["Clinical Implant Dentistry and Related Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcid.12713","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cid.12713","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cid.12713","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cid.12713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T22:31:51Z","timestamp":1694385111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cid.12713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,28]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/cid.12713"],"URL":"https:\/\/doi.org\/10.1111\/cid.12713","archive":["Portico"],"relation":{},"ISSN":["1523-0899","1708-8208"],"issn-type":[{"value":"1523-0899","type":"print"},{"value":"1708-8208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,28]]},"assertion":[{"value":"2018-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}