{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:11:44Z","timestamp":1771024304928,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:00:00Z","timestamp":1553040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["CTS\u20101028"],"award-info":[{"award-number":["CTS\u20101028"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["CTS\u2010138"],"award-info":[{"award-number":["CTS\u2010138"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Poly (lactic\u2010co\u2010glycolic acid) (PLGA) is widely used for the development of delivery systems for drugs and therapeutic biomolecules in tissue engineering applications. Particles of biphasic calcium phosphate can be covered by PLGA to change their manipulating characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Aim of this study was to investigate the radiological and histomorphometric results of the use of PLGA\u2010coated biphasic calcium phosphate granules in sinus floor elevation and to analyze the underlying molecular processes by immunohistochemical staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A randomized clinical study was designed to include patients in need of sinus floor elevation. Patients were assigned to receive either PLGA\u2010coated biphasic calcium phosphate particles (group I) or the equivalent but noncoated particles (group II). Cone beam computed tomography (CBCT) scans were performed before and 6 months after the procedure to assess the bone height gain. At the time of implant placement, bone core biopsies were obtained at the site of implant placement. Histological sections were subjected to histomorphometric and immunohistochemical evaluation of differentiation markers (Musashi\u20101 [MSI1]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant differences were observed between groups for the radiologic parameters. No differences were observed histologically or histomorphometrically. However, PLGA\u2010coated particles (group I) were more colonized by MSI1\u2010positive osteoblast precursors (<jats:italic>P<\/jats:italic>\u2009=\u20090.0001, chi\u2010squared test) and were penetrated by more CD34\u2010positive vascular structures (<jats:italic>P<\/jats:italic>\u2009=\u20090.001, chi\u2010squared test) than noncoated particles (group II).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PLGA\u2010coated particles are associated with more MSI11\u2010positive cells and more extensive microvascularization than noncoated particles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12741","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T06:56:11Z","timestamp":1553151371000},"page":"895-902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sinus floor elevation using particulate PLGA\u2010coated biphasic calcium phosphate bone graft substitutes: A prospective histological and radiological study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6543-1598","authenticated-orcid":false,"given":"Antonio J.","family":"Flichy\u2010Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Implantology Valencia University Medical and Dental School  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Blaya\u2010T\u00e1rraga","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implantology Valencia University Medical and Dental School  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"O'Valle","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine &amp; Biopathology and Medicine Regenerative Institute (IBIMER, CIBM), University of Granada  Granada 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