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Ceramic\u2010based reconstructions were cemented in either zirconia or titanium abutments. Clinical, radiographic, and microbiological outcomes were examined at implant loading and then yearly up to 3\u2009years post\u2010loading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cumulative survival\/success implant rates were 95% after 3\u2009years. Mean total marginal bone loss was 0.76\u2009\u00b1\u20090.21\u2009mm for zirconia and 0.99\u2009\u00b1\u20090.41\u2009mm for titanium, with no significant differences (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). Overall, titanium and zirconia abutments presented similar values of probing depth, gingival recession, and bleeding on probing over time (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Microbial profile of implants restored with titanium or zirconia is quite similar to that found in the remaining teeth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Zirconia and titanium presented different microbial profile and genome counts. Clinical findings for both zirconia and titanium abutments were similar and consistent with a healthy condition, reflecting a high survival rate and low bone loss. Microbiota did not impact the clinical outcomes after 3\u2009years of function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12888","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T04:15:53Z","timestamp":1580962553000},"page":"301-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A 3\u2010year longitudinal prospective study assessing microbial profile and clinical outcomes of single\u2010unit cement\u2010retained implant restorations: Zirconia versus titanium abutments"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6848-0763","authenticated-orcid":false,"given":"Thalisson S.","family":"de Oliveira Silva","sequence":"first","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, Faculty of Dentistry of Ribeir\u00e3o Preto, Molecular Diagnosis Laboratory University of S\u00e3o Paulo Ribeir\u00e3o Preto S\u00e3o Paulo 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