{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:04:25Z","timestamp":1790949865359,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peri\u2010implantitis is the inflammatory process, which most commonly affects the therapy with dental implants. However, there are other reactive and neoplastic entities, mainly benign but also malignant, which also take place in the peri\u2010implant mucosa. There is little information about the histopathological analysis of these peri\u2010implant inflammatory diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To analyze the histopathological diagnosis of biopsies located in the peri\u2010implant mucosa that showed an inflammatory clinical appearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We have made a retrospective study of 111 peri\u2010implant biopsies analyzed in the Oral and Maxillofacial Pathology Unit of the Dental Clinic Service at the University of the Basque Country, from January 2001 to December 2018. These samples corresponded to 84 women and 27 men, whose mean age was 59\u2009years. We performed a standard histological processing with paraffin embedding, and sections were stained with H&amp;E and PAS. All cases were analyzed following a specific diagnostic histopathological protocol. A descriptive statistical analysis was carried out with the obtained data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lesions located in the mandible (64.8%) were more frequent and 34.2% of the biopsies arrived without a presumptive clinical diagnosis. \u201cInflammatory peri\u2010implant lesion\u201d or peri\u2010implantitis was the most common clinical diagnosis. Histopathologically, the majority of the lesions were peri\u2010implant nonspecific inflammatory hyperplasia (60.3%), followed by peripheral giant cell granuloma (18.1%), pyogenic granuloma (lobular capillary hemangioma) (14.4%), actinomicotic infection (3.6%), and squamous cell carcinoma (3.6%). Individually, peri\u2010implant lesions were more common among women and in the mandible, except for actinomicotic infection and squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An important percentage of cases whose initial presumptive clinical diagnosis was \u201cperi\u2010implant inflammatory lesion\u201d truly corresponded to other reactive and neoplastic processes. Thus, it is key to always submit all the tissue removed during the implant surgery, in order to perform a good histopathological study and achieve the correct final diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12905","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T09:45:08Z","timestamp":1588844708000},"page":"366-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Histopathological analysis of biopsies of \u201cperi\u2010implant inflammatory lesions.\u201d Everything is not what it seems"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5118-9913","authenticated-orcid":false,"given":"Didac","family":"Sotorra\u2010Figuerola","sequence":"first","affiliation":[{"name":"Oral Pathology Master Programme, Oral and Maxillofacial Pathology Unit, Dental Clinic Service, Department of Stomatology II University of the Basque Country (UPV\/EHU)  Leioa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-4122","authenticated-orcid":false,"given":"Irene","family":"Lafuente\u2010Ib\u00e1\u00f1ez de Mendoza","sequence":"additional","affiliation":[{"name":"Oral Pathology Master Programme, Oral and Maxillofacial Pathology Unit, Dental Clinic Service, Department of Stomatology II University of the Basque Country (UPV\/EHU)  Leioa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Parra\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Oral Pathology Master Programme, Oral and Maxillofacial Pathology Unit, Dental Clinic Service, Department of Stomatology II University of the Basque Country (UPV\/EHU)  Leioa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2652-0755","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Aguirre\u2010Urizar","sequence":"additional","affiliation":[{"name":"Oral Pathology Master Programme, Oral and Maxillofacial Pathology Unit, Dental Clinic Service, Department of Stomatology II University of the Basque Country (UPV\/EHU)  Leioa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0157"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12954"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12137"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.08.023"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2005.01843.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.06.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/839032"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-13-00155"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090081"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-11-00143"},{"issue":"1","key":"e_1_2_7_13_1","first-page":"53","article-title":"Peripheral giant cell granuloma. 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