{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:56:04Z","timestamp":1782536164906,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To assess the influence of ridge preservation procedures on the healing of extraction sockets under antiresorptive therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 10 Dutch Belted rabbits were randomly allocated to either the intravenous administration of amino\u2010bisphosphonate (zoledronic acid) (Za) (n = 5) or a negative control group (no Za [nZa]) (n = 5). At 6\u2009months, the mandibular and maxillary molars were extracted and the four experimental sites randomly allocated to the following subgroups: (a) socket grafting using a collagen\u2010coated natural bone mineral (BOC)\u2009+\u2009primary wound closure, (b) coronectomy (CO), or (c) spontaneous healing\u2009+\u2009primary wound closure (SP). Za medication was continued for another 4 months. Histomorphometrical analyses considered, for example, crestal hard tissue closure of the extraction site (C) and mineralized tissue (MT) formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Za\u2010SP was associated with an incomplete median C (31.76% vs 100% in nZa\u2010SP) and signs of bone arrosion along the confines of the socket. BOC had no major effects on increases in C and MT values in the Za group. CO commonly resulted in an encapsulation and partial replacement resorption of residual roots by MT without any histological signs of osteonecrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>(a) Za\u2010SP was commonly associated with a compromised socket healing and signs of osteonecrosis, (b) BOC had no major effect on socket healing in the Za group, and (c) CO at noninfected teeth might be a feasible measure for the prevention of a Za\u2010related osteonecrosis of the jaw.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.12916","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T07:20:01Z","timestamp":1592205601000},"page":"477-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Influence of ridge preservation procedures on extraction socket healing under antiresorptive therapy: An experimental study in rabbits"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5873-9903","authenticated-orcid":false,"given":"Frank","family":"Schwarz","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Implantology, Carolinum Goethe University  Frankfurt Germany"},{"name":"Department of Oral Surgery Universit\u00e4tsklinikum D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"John","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Universit\u00e4tsklinikum D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Universit\u00e4tsklinikum D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut 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