{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:35:52Z","timestamp":1791477352652,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the effect of early bone loss (EBL), on long\u2010term bone stability and future peri\u2010implantitis development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Patients referred for implant placement between 2005 and 2009 were consecutively treated and followed for 10\u2009years. After 10\u2009years, patients were invited for a scientific diagnostic visit to evaluate implant survival and bone loss. Bone level changes were compared with baseline. Non\u2010parametric testing was performed in cross\u2010tabs (Pearson Chi\u2010square and Fishers's exact test). Kaplan\u2013Meier\u2010estimated survival curves were plotted for different thresholds for EBL at different timepoints. Generalized linear mixed models with binomial distribution and logit link for peri\u2010implantitis were fitted. An adjusted logistic mixed model was made to evaluate peri\u2010implantitis, in relation with smoking status, history of periodontitis, and EBL\u2009&gt;\u20090.5\u2009mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four hundred and seven patients (mean age of 64.86\u2009years [range 28\u201392, SD 10.11]), with 1482 implants, responded to the 10\u2010year recall invitation. After an average follow\u2010up time of 10.66\u2009years (range 10\u201314, SD 0.87), implant survival was 94.74%. Mean crestal bone loss after 10\u2009years was 0.81\u2009mm (SD 1.58, range 0.00\u201317.00). One hundred and seventy five implants in 76 patients had peri\u2010implantitis (11.8% on implant level, 18.7% on patient level). EBL of 0.5, 1, and 2\u2009mm were significant predictors for peri\u2010implantitis and implant loss after 10\u2009years. Implants with EBL \u22650.5\u2009mm during the first year of function showed a 5.43 times higher odds for future peri\u2010implantitis development. Probability in developing peri\u2010implantitis was 52.06% when smoking, Periodontal history and EBL of &gt;0.5\u2009mm was combined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present study suggests that EBL is a predictor for long\u2010term peri\u2010implant pathology, with a significant higher risk for peri\u2010implantitis when early bone loss exceeds the thresholds of 0.5 and 1\u2009mm, especially when additional risk factors such as smoking or susceptibility for periodontal disease prior to implant treatment are present.<\/jats:p>\n                    <jats:p>Clinical trial registration number B670201524796.<\/jats:p>\n                  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