{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:19:54Z","timestamp":1789233594109,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiotherapy aggravates implant\u2010based prosthetic rehabilitation in patients with head and neck cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the impact of radiation dose at implant and parotid gland site for prosthetic rehabilitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>The retrospective study includes 121 irradiated head and neck cancer patients with 751 inserted implants. Radiation doses on implant bed and parotid gland site were recorded by 3\u2010dimensional modulated radiation plans. Implant success was clinically and radiographically evaluated according to modified Albrektsson criteria and compared to treatment\u2010 and patient\u2010specific data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Implant overall survival after 5\u2009years was 92.4% with an implant success rate of 74.9%. Main reasons for implant failure were marginal bone resorption (20.9%), implant not in situ or unloaded (9.6%) and peri\u2010implantitis (7.5%). A mean radiation dose of 62.6\u00a0Gy was applied with a mean parotid dose of 35\u2009Gy. Modulating radiation techniques went along with lower grades of xerostomia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). At implant site mean doses of 57.5, 42.0, and 32.3\u00a0Gy were recorded for oral, oropharyngeal, and hypopharyngeal\/laryngeal carcinoma, respectively. Implant success inversely correlated to radiation dose at implant site. Strong predictors for implant failure in uni\u2010 and multivariate analysis were implant\u2010specific dose &gt;50\u2009Gy (HR 7.9), parotid dose &gt;30\u2009Gy (HR 2.3), bone (HR 14.5) and soft tissue (HR 4.5) transplants, bad oral hygiene (HR 3.8), nonmodulated radiation treatment planning (HR 14.5), and nontelescopic prosthetics (HR 5.2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Radiotherapy impedes implant success in a dose\u2010dependent manner at implant site. Modern radiation techniques effectively reduce xerostomia favoring implant\u2010based prosthetic rehabilitation. Implantation in bone grafts is more critical and telescopic\u2010retained overdentures should be preferred.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.13005","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:36:55Z","timestamp":1620175015000},"page":"444-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Significance of site\u2010specific radiation dose and technique for success of implant\u2010based prosthetic rehabilitation in irradiated head and neck cancer patients\u2014A cohort study"],"prefix":"10.1111","volume":"23","author":[{"given":"Franziska","family":"Wolf","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Spoerl","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Gottsauner","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Klingelh\u00f6ffer","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"Spanier","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Kolbeck","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten E.","family":"Reichert","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias G.","family":"Hautmann","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0549-5351","authenticated-orcid":false,"given":"Tobias","family":"Ettl","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Gesichtschirurgie; DGfM\u2010K\u2010u E. 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