{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:39:40Z","timestamp":1792726780225,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical benefits of local antibiotics as an adjunct to nonsurgical treatment of peri\u2010implantitis have been widely reported, but most studies evaluated incipient peri\u2010implantitis lesions, and showed incomplete treatment success rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the clinical and microbiological outcomes of administering metronidazole in combination with minocycline as a local adjunct to the nonsurgical treatment of peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>One hundred and eighteen subjects with peri\u2010implantitis were recruited in a four\u2010center, three\u2010arm, and 12\u2010week randomized controlled trial. Subjects were randomly assigned to receive one of the following treatments: (a) MM\u2014mechanical debridement\u2009+\u2009metronidazole\u2010minocycline ointment, (b) MC\u2014mechanical debridement\u2009+\u2009minocycline ointment, (c) NST\u2014mechanical debridement only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Except for four subjects who was excluded during the trial, a total of 114 patients with 114 implants (one implant per each patient) finally completed the trial and were included in the analyses. Multivariate logistic regression analysis revealed that the treatment success rates (absence of bleeding or suppuration on probing, and sites showing pocket probing depth [PPD] \u22655\u2009mm) on at 12\u2009weeks were higher in MM\u2010group patients (31.6%) and MC\u2010group patients (20.5%) compared to NST\u2010group patients (2.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011 and 0.040, respectively). Subjects with deepest PPD \u22658\u2009mm showed a significant difference in the PPD reduction between MM and MC groups at week 4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.025) and week 12 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.047). Detection ratio of\n                      <jats:italic>Tannerella forsythia<\/jats:italic>\n                      was significantly lower for MM group than MC group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.038).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Additive use of either MM or MC results in significantly higher treatment success rates compared to sole mechanical debridement in nonsurgical treatment of peri\u2010implantitis. Moreover, MM contributes to a significantly greater reduction in the PPD compared to MC in deep pockets (cris.nih.go.kr KCT0004557).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.13006","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T13:02:52Z","timestamp":1623934972000},"page":"543-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Adjunctive use of metronidazole\u2010minocycline ointment in the nonsurgical treatment of peri\u2010implantitis: A multicenter randomized controlled trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-8036","authenticated-orcid":false,"given":"Seung\u2010Hyun","family":"Park","sequence":"first","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1835-5646","authenticated-orcid":false,"given":"Young Woo","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6906-7209","authenticated-orcid":false,"given":"Jae\u2010Kook","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-5978","authenticated-orcid":false,"given":"Jung\u2010Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-5783","authenticated-orcid":false,"given":"Young\u2010Taek","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Periodontology National Health Insurance Service Ilsan Hospital  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1410-9731","authenticated-orcid":false,"given":"Hyun\u2010Seung","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dankook University College of Dentistry  Cheonan\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-7989","authenticated-orcid":false,"given":"Dong\u2010Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology Gangnam Severance Dental Hospital, College of Dentistry, Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2739-281X","authenticated-orcid":false,"given":"Jae Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"MXBIO Corporation  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3902-1071","authenticated-orcid":false,"given":"Chang\u2010Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g5.3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01276.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02542.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00919.x"},{"issue":"1","key":"e_1_2_11_7_1","first-page":"59","article-title":"Topical treatment of peri\u2010implantitis with metronidazole dental gel 25%. 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