{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:56Z","timestamp":1787014016563,"version":"build-2736575974"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the efficacy of using a bone substitute material (BSM) in the fixture\u2013socket gap in patients undergoing tooth extraction and immediate implant placement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>MEDLINE, EMBASE, and CENTRAL databases were searched for randomized controlled trials (RCTs). RCTs were screened for eligibility, and data were extracted by two authors independently. Risk of bias (ROB) was assessed using Cochrane's ROB tool 2.0. Primary outcomes were implant failure, overall complications, and soft\u2010tissue esthetics. Secondary outcomes were vertical buccal bone resorption, vertical interproximal bone resorption, horizontal buccal bone resorption, and mid\u2010buccal mucosal recession. Meta\u2010analysis was performed using random\u2010effects model with generic inverse variance weighing. GRADE was used to grade the certainty of the evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After screening 19\u2009544 potentially eligible references, 20 RCTs were included in this review, with a total of 848 patients (916 sites). Most included RCTs were deemed of some concerns (53%) or at low (38%) risk of bias, except for overall complications (high ROB). Implant failure did not differ significantly RR\u00a0=\u00a00.92 (confidence intervals [CI] 0.34 to 2.46) between using a BSM compared with not using a BSM (NoBSM). BSM use resulted in less horizontal buccal bone resorption (MD\u00a0=\u00a0\u22120.52\u2009mm [95% CI \u22120.74 to \u22120.30]), a higher esthetic score (MD\u00a0=\u00a01.49 [95% CI 0.46 to 2.53]), but also more complications (RR\u00a0=\u00a03.50 [95% CI 1.11 to 11.1] compared with NoBSM. Too few trials compared types of BSMs against each other to allow for pooled analyses. The certainty of the evidence was considered moderate for all outcomes except implant failure (low), overall complications (very low), and vertical interproximal bone resorption (very low).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BSM use during immediate implant placement reduces horizontal buccal bone resorption and improves the periimplant soft\u2010tissue esthetics. Although BSM use increases the risk of predominantly minor complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.13014","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T14:08:55Z","timestamp":1623506935000},"page":"506-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Efficacy of bone\u2010substitute materials use in immediate dental implant placement: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2180-4094","authenticated-orcid":false,"given":"John","family":"Zaki","sequence":"first","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University  Utrecht The Netherlands"},{"name":"Maidan Dental Clinic  Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermin","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"El\u2010Khadem","sequence":"additional","affiliation":[{"name":"The Centre for Evidence\u2010Based Dentistry, Faculty of Dentistry Cairo University  Giza Egypt"},{"name":"Department of Pediatric Dentistry, Faculty of Dentistry Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob J. 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