{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:31:20Z","timestamp":1787761880501,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nonsurgical treatment, resective surgery, reconstructive surgery, or combined approaches have been proposed for the treatment of peri\u2010implantitis, with variable results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the 1\u2010year clinical and radiographic outcomes following combined resective and reconstructive surgical treatment with topical piperacillin\/tazobactam antibiotic in the management of peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Forty\u2010three patients diagnosed with peri\u2010implantitis were included. Surgical treatment consisted of implantoplasty of the supra\u2010crestal component of the defect, the application of a topical antibiotic solution over the implant surface, and subsequent reconstruction of the intra\u2010osseous component of the peri\u2010implant defect. The primary outcome was disease resolution, defined as the absence of bleeding on probing (BoP) and\/or suppuration on probing (SoP), a peri\u2010implant pocket probing depth (PPD) \u22645\u2009mm, and no bone loss &gt;0.5\u2009mm 1\u2009year after surgery. Secondary outcomes included changes in BoP, PPD, SoP, and peri\u2010implant marginal bone levels. One implant per patient was included in the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The treatment success rate of the 43 dental implants included in the study was 86% at 1\u2009year after surgery. Mean PPD and BoP decreased from 6.41\u2009\u00b1\u20092.11\u2009mm and 100% at baseline to 3.19\u2009\u00b1\u20090.99\u2009mm (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) and 14% (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) at 1\u2009year, respectively. SoP was significantly reduced from 48.8% at baseline to 0% 1\u2009year after surgery (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). Radiographically, a mean defect fill of 2.64\u2009\u00b1\u20091.59\u2009mm was recorded (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of a resective and reconstructive surgical approach together with locally delivered antibiotic achieved a high disease resolution rate after 1\u2009year of follow\u2010up and constitutes a viable option for the management of peri\u2010implantitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13049","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T16:35:57Z","timestamp":1634488557000},"page":"864-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Surgical approach combining implantoplasty and reconstructive therapy with locally delivered antibiotic in the treatment of peri\u2010implantitis: A prospective clinical case series"],"prefix":"10.1111","volume":"23","author":[{"given":"Iria","family":"Gonz\u00e1lez Regueiro","sequence":"first","affiliation":[{"name":"Hospital Virgen de La Paloma  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4395-5953","authenticated-orcid":false,"given":"Natalia","family":"Mart\u00ednez Rodriguez","sequence":"additional","affiliation":[{"name":"Hospital Virgen de La Paloma  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0966-3276","authenticated-orcid":false,"given":"Cristina","family":"Barona Dorado","sequence":"additional","affiliation":[{"name":"School of Dentistry Complutense University of Madrid  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3698-4772","authenticated-orcid":false,"given":"Ignacio","family":"Sanz\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases (ETEP) Research Group University Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2525-8529","authenticated-orcid":false,"given":"Eduardo","family":"Montero","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases (ETEP) Research Group University Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6542-5710","authenticated-orcid":false,"given":"Javier","family":"Ata\u2010Ali","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Dentistry Universidad Europea de Valencia  Valencia Spain"},{"name":"Public Dental Health Service Conselleria de Sanitat Universal i Salut P\u00fablica, Generalitat Valenciana  Valencia Spain"},{"name":"Department of Surgery and Medical\u2010Surgical Specialities, Area of Orthodontics University Medical and Dental School, University of Oviedo (Spain), Instituto Asturiano de Odontologia  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Duarte","sequence":"additional","affiliation":[{"name":"Instituto Clitrofa  Trofa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6192-3656","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Mart\u00ednez\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"School of Dentistry Complutense University of Madrid  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0588"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12334"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516667484"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13017"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.17227"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515601961"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01837.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12505"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13287"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13711"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01320.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01867.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01690.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13256"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2310-0"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13628"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12727"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12913"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12369"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12049"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10051107"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2016.7313"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g5.3"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12648"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12183"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170123"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13441"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12349"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12813"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12160"},{"key":"e_1_2_11_33_1","unstructured":"Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios.Ficha t\u00e9cnica piperacilina\/tazobactam.2021 January. Available from:http:\/\/www.aemps.gob.es\/"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-019-0866-6"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-12-00030"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02098.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01540.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12986"}],"container-title":["Clinical Implant Dentistry and Related Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cid.13049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cid.13049","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cid.13049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T22:47:06Z","timestamp":1693003626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cid.13049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,14]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/cid.13049"],"URL":"https:\/\/doi.org\/10.1111\/cid.13049","archive":["Portico"],"relation":{},"ISSN":["1523-0899","1708-8208"],"issn-type":[{"value":"1523-0899","type":"print"},{"value":"1708-8208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,14]]},"assertion":[{"value":"2021-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}