{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:46:59Z","timestamp":1785296819539,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The effect of different deproteinized bovine bone mineral (DBBM) particle sizes on bone healing in maxillary sinus floor augmentation remains unclear. This study compared the newly formed tissue and angiogenesis\u2010related bone healing after sinus floor augmentation using large or small DBBM particles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Overall 32 patients were randomly divided into two groups using either large (1\u20132\u2009mm) or small (0.25\u20131\u2009mm) DBBM particles for sinus floor augmentation. After 6\u00a0months, the mineralized tissue volume was calculated using micro\u2010computed tomography (micro\u2010CT) analysis. The newly formed tissue composition was histomorphometrically analyzed. Angiogenesis was also examined by means of vascular endothelial growth factor (VEGF) expression. Implant failure and marginal bone loss were measured at a 1\u2010year follow\u2010up. Statistical analysis was performed using independent samples <jats:italic>t<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Micro\u2010CT analysis demonstrated that grafting with large particles resulted in higher bone volume (6.99\u2009\u00b1\u20092.72\u2009mm<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and Bone Volume\/Tissue Volume (0.25\u2009\u00b1\u20090.1, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) compared with small particles (3.76\u2009\u00b1\u20091.83\u2009mm<jats:sup>3<\/jats:sup> and 0.14\u2009\u00b1 0.13, respectively). Small particles showed higher non\u2010mineralized tissue volume (26.31\u2009mm<jats:sup>3<\/jats:sup>) compared with large particle group (17.4\u2009\u00b1\u20095.34\u2009mm<jats:sup>3<\/jats:sup>) with <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001. The histological data revealed significantly higher area of newly formed bone (32.15%\u2009\u00b1\u200914.04% for the large particle and 15.99%\u2009\u00b1\u200914.12% for the small particle groups, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004). Likewise, non\u2010mineralized tissue was significantly greater in the small particle group (66.48%\u2009\u00b1\u200920.97%) compared with the large particle group (44.36%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.016). Moreover, use of large particles resulted in a significantly higher VEGF staining intensity score and VEFG positive cells. No implant failure was recorded in both groups, while no difference was found in terms of marginal bone loss at the 1\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sinus floor augmentation using large DBBM particles resulted in more angiogenesis expression, higher bone volume, and new bone formation at 6\u00a0months after sinus augmentation. However, clinical outcomes with regards to implant placement were similar in both groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cid.13083","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T20:40:35Z","timestamp":1648068035000},"page":"361-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The impact of deproteinized bovine bone particle size on histological and clinical bone healing outcomes in the augmented sinus: A randomized controlled clinical trial"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5304-5865","authenticated-orcid":false,"given":"Paksinee","family":"Kamolratanakul","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Department of Oral and Maxillofacial Surgery Chulalongkorn University  Bangkok 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