{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:08:54Z","timestamp":1787062134542,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016036","name":"Health~Holland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Implant Dent Rel Res"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Mandibular retromolar (predominantly cortical) and maxillary tuberosity (predominantly cancellous) bone grafts are used in patients undergoing maxillary sinus floor elevation (MSFE) for dental implant placement. The aim of this retrospective cohort study was to investigate whether differences exist in bone formation and vascularization after grafting with either bone source in patients undergoing MSFE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifteen patients undergoing MSFE were treated with retromolar (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u20099) or tuberosity (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u20096) bone grafts. Biopsies were taken 4\u00a0months postoperatively prior to dental implant placement, and histomorphometrically analyzed to quantify bone and osteoid area, number of total, apoptotic, and receptor activator of nuclear factor\u2010\u03baB ligand (RANKL)\u2010positive osteocytes, small and large\u2010sized blood vessels, and osteoclasts. The grafted area was divided in three regions (caudal\u2010cranial): RI, RII, and RIII.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bone volume was 40% (RII, RIII) higher and osteoid volume 10% (RII) lower in retromolar compared to tuberosity\u2010grafted areas. Total osteocyte number and number of RANKL\u2010positive osteocytes were 23% (RII) and 90% (RI, RII) lower, but osteoclast number was higher (retromolar: 12, tuberosity: 0) in retromolar\u2010grafted areas. The total number of blood vessels was 80% (RI) to 60% (RIII) lower, while the percentage of large\u2010sized blood vessels was 86% (RI) to 25% (RIII) higher in retromolar\u2010grafted areas. Number of osteocyte lacunae and apoptotic osteocytes were similar in both bone grafts used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared to the retromolar bone, tuberosity bone showed increased bone vitality and vascularization in patients undergoing MSFE, likely due to faster bone remodeling or earlier start of new bone formation. Therefore, tuberosity bone grafts might perform better in enhancing bone regeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.13142","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T10:29:38Z","timestamp":1665397778000},"page":"141-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Bone vitality and vascularization of mandibular and maxillary bone grafts in maxillary sinus floor elevation: A retrospective cohort study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7881-0829","authenticated-orcid":false,"given":"Vivian","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam Movement Sciences  Amsterdam The Netherlands"},{"name":"Department of Oral and Maxillofacial Surgery\/Oral Pathology, Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA) Vrije Universiteit Amsterdam, Amsterdam Movement Sciences  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engelbert A. 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M.","family":"Schulten","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery\/Oral Pathology, Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA) Vrije Universiteit Amsterdam, Amsterdam Movement Sciences  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3195-1223","authenticated-orcid":false,"given":"Marco N.","family":"Helder","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery\/Oral Pathology, Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA) Vrije Universiteit Amsterdam, Amsterdam Movement Sciences  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan M.","family":"ten Bruggenkate","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery\/Oral Pathology, Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA) Vrije Universiteit Amsterdam, Amsterdam Movement Sciences  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bravenboer","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam Movement Sciences  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenneke","family":"Klein\u2010Nulend","sequence":"additional","affiliation":[{"name":"Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam Movement Sciences  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"issue":"8","key":"e_1_2_10_2_1","first-page":"613","article-title":"Grafting of the maxillary sinus floor with autogenous marrow and 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