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Epidemiological reports, though, indicate that peri\u2010implantitis is a site\u2010specific entity. Hence, the significance of local factors that may predispose\/precipitate plaque accumulation and the impact of systemic drivers that alter the immune response are relevant in the prevention and management of peri\u2010implant disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of the present review is to shed light on the significance of local and systemic factors on peri\u2010implant diseases, making special emphasis on the associations with peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The biologic plausibility and supporting evidence aiming at providing a concluding remark were explored in the recent scientific literature for local predisposing\/precipitating factors and systemic drivers related to peri\u2010implant diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Local predisposing factors such as soft tissue characteristics, implant position and prosthetic design proved being strongly associated with the occurrence of peri\u2010implant diseases. Hard tissue characteristics, however, failed to demonstrate having a direct association with peri\u2010implant diseases. Robust data points toward the strong link between residual sub\u2010mucosal cement and peri\u2010implant diseases, while limited data suggests the impact of residual sub\u2010mucosal floss and peri\u2010implantitis. Systemic drivers\/habits such as hyperglycemia and smoking showed a strong negative impact on peri\u2010implantitis. However, there is insufficient evidence to claim for any link between metabolic syndrome, atherosclerotic cardiovascular disease, and obesity and peri\u2010implant diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Local predisposing\/precipitating factors and systemic drivers may increase the risk of peri\u2010implant diseases. Therefore, comprehensive anamnesis of the patients, educational\/motivational programs and exhaustive prosthetically\u2010driven treatment planning must be fostered aiming at reducing the rate of biological complications in implant dentistry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cid.13155","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T04:16:31Z","timestamp":1671423391000},"page":"640-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Impact of local predisposing\/precipitating factors and systemic drivers on peri\u2010implant diseases"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8292-1927","authenticated-orcid":false,"given":"Alberto","family":"Monje","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Periodontology Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"Department of Periodontology, ZMK University of Bern  Bern CH Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Y.","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Implantology Loma Linda University  Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenche","family":"Borgnakke","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Medicine University of Michigan  Ann Arbor Michigan 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